Thymic neuroendocrine tumors (paraganglioma and carcinoid tumors): a comparative immunohistochemical study of 46 cases

Weissferdt, Annikka; Kalhor, Neda; Liu, Hui; Rodríguez, Jaime; Fujimoto, Junya; Tang, Ximing; Wistuba, Ignacio I.; Moran, César A.

doi:10.1016/j.humpath.2014.08.013

Cited by 35 publications

(26 citation statements)

References 32 publications

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“…In addition, the staining can be negative if sustentacular cells are not present in a limited cell block such as in case 1. Recent studies demonstrate that GATA‐3, Pax 8, and tyrosine hydroxylase may be useful to distinguish these two entities . In one study, paragangliomas were immunoreactive to GATA‐3 in 55% of the cases from any anatomic site, compared to carcinoid tumors which were nonreactive in all cases .…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies demonstrate that GATA‐3, Pax 8, and tyrosine hydroxylase may be useful to distinguish these two entities . In one study, paragangliomas were immunoreactive to GATA‐3 in 55% of the cases from any anatomic site, compared to carcinoid tumors which were nonreactive in all cases . Several other studies demonstrated that Pax‐8 had a sensitivity of up to 88% and specificity of 74% for primary NET of pancreatic origin .…”

Section: Discussionmentioning

confidence: 99%

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Peripancreatic paraganglioma mimics pancreatic/gastrointestinal neuroendocrine tumor on fine needle aspiration: Report of two cases and review of the literature

Zeng

Simsir

Oweity

et al. 2017

Diagnostic Cytopathology

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Cytologic diagnosis of extra-adrenal paraganglioma presenting as a peripancreatic mass is challenging with a high error rate due to its rarity. We report two cases of peripancreatic masses identified by radiology. Endoscopic ultrasound-guided fine needle aspiration (FNA) of the masses showed a moderately cellular tumor composed of small to medium sized neoplastic cells with round to oval nuclei, arranged singly and in loose clusters. Focal rosette-like structures were present. The cells were positive for neuroendocrine markers (synaptophysin and chromogranin). A diagnosis of a neoplasm with neuroendocrine differentiation and neuroendocrine tumor was made respectively on FNA for each case. The subsequent surgical resection of the tumors revealed peripancreatic paraganglioma. Although paraganglioma has been reported in the literature, the detailed comparison of perpancreatic paraganglioma versus pancreatic/gastrointestinal neuroendocrine tumor is still lacking. Therefore using these two cases with literature review, we wish to illustrate the differential diagnosis between these two entities based on cytomorphology and immunohistochemical study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Peripancreatic paraganglioma mimics pancreatic/gastrointestinal neuroendocrine tumor on fine needle aspiration: Report of two cases and review of the literature

Zeng

Simsir

Oweity

et al. 2017

Diagnostic Cytopathology

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“…The higher incidence of TTF-1 positivity in 91% of high-grade NEC cases was noted when using the SPT24 clone, as compared with the 64% of cases detected using the 8G7G3/1 clone [21]. After the comparative immunohistochemical study, Weissferdt et al showed the TTF-1 positivity of 8-17%, and 76% in low and intermediate grade TNECs and PNECs, respectively, using the 8G7G3/ 1 clone of TTF-1 antibody [5,22]. However, TTF-1 expression in our cases showed positivity of 95% for PNECs and 59.1% for TNECs.…”

Section: Discussionmentioning

confidence: 99%

Immunophenotypic and prognostic analysis of PAX8 and TTF‐1 expressions in neuroendocrine carcinomas of thymic origin: A comparative study with their pulmonary counterparts

Deng

et al. 2016

Journal of Surgical Oncology

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Our study demonstrated that TTF-1/PAX8 immunophenotyping may be helpful for differential diagnosis of NECs of pulmonary and thymic origins. TTF-1+/PAX8- immunophenotyping showed high specificity for PNECs, while PAX8+ alone showed a good diagnostic accuracy for TNEC. Lung metastasis was a predictive factor that associated with survival of TNEC patients. J. Surg. Oncol. 2016;114:697-702. © 2016 Wiley Periodicals, Inc.

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“…Cytokeratin and PAX8 are positive in neuroendocrine tumors while cytokeratin expression is variable in paraganglioma . Vimentin and GATA‐3 are positive in paraganglioma and negative in neuroendocrine tumors . Tyrosine hydroxylase is immunoreactive for paraganglioma .…”

Section: Discussionmentioning

confidence: 99%

“…12 Vimentin and GATA-3 are positive in paraganglioma and negative in neuroendocrine tumors. 9,18,19 Tyrosine hydroxylase is immunoreactive for paraganglioma. 19 Staining patterns in our cases were consistent with published reports on the staining profiles of paragangliomas.…”

Section: Follow-upmentioning

confidence: 99%

Paraganglioma: Cytomorphologic features, radiologic and clinical findings in 12 cases

Fite

Maleki

2018

Diagnostic Cytopathology

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An accurate diagnosis of paraganglioma on FNA specimens is crucial for proper treatment. SDH status should be considered for all patients with paraganglioma as it may be important for patients' lifelong follow-up as well as for familial considerations. Paraganglioma is a rare entity with wide age and anatomic distribution and variable cytomorphological features that often overlap with those of malignant neoplasms. Possible aggressive behavior such as recurrence and metastasis to lymph nodes, bone, and lung as well as Succinate Dehydrogenase complex mutations warrant an accurate diagnosis on aspirated material for appropriate clinical management.

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Thymic neuroendocrine tumors (paraganglioma and carcinoid tumors): a comparative immunohistochemical study of 46 cases

Cited by 35 publications

References 32 publications

Peripancreatic paraganglioma mimics pancreatic/gastrointestinal neuroendocrine tumor on fine needle aspiration: Report of two cases and review of the literature

Peripancreatic paraganglioma mimics pancreatic/gastrointestinal neuroendocrine tumor on fine needle aspiration: Report of two cases and review of the literature

Immunophenotypic and prognostic analysis of PAX8 and TTF‐1 expressions in neuroendocrine carcinomas of thymic origin: A comparative study with their pulmonary counterparts

Paraganglioma: Cytomorphologic features, radiologic and clinical findings in 12 cases

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