Thymic Indoleamine 2,3-Dioxygenase-Positive Eosinophils in Young Children

Tulic, Meri K.; Sly, Peter D.; Andrews, David; Crook, Maxine L.; Davoine, Francis; Odemuyiwa, Solomon O.; Charles, Adrian; Hodder, Megan; Prescott, Susan L.; Holt, Patrick G.; Moqbel, Redwan

doi:10.2353/ajpath.2009.090015

Cited by 37 publications

(43 citation statements)

References 38 publications

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“…Similarly, in prepubertal mammary glands, eosinophils together with macrophages regulate normal breast ductal development [11,12]. Furthermore, eosinophils accumulate in the thymus of the newborn and it has been suggested that they contribute to class I restricted thymocyte selection [11,13,14].…”

Section: Introductionmentioning

confidence: 99%

Eosinophils: important players in humoral immunity

Berek

2015

Clinical and Experimental Immunology

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Summary Eosinophils perform numerous tasks. They are involved in inflammatory reactions associated with innate immune defence against parasitic infections and are also involved in pathological processes in response to allergens. Recently, however, it has become clear that eosinophils also play crucial non‐inflammatory roles in the generation and maintenance of adaptive immune responses. Eosinophils, being a major source of the plasma cell survival factor APRIL (activation and proliferation‐induced ligand), are essential not only for the long‐term survival of plasma cells in the bone marrow, but also for the maintenance of these cells in the lamina propria which underlies the gut epithelium. At steady state under non‐inflammatory conditions eosinophils are resident cells of the gastrointestinal tract, although only few are present in the major organized lymphoid tissue of the gut – the Peyer's patches (PP). Surprisingly, however, lack of eosinophils abolishes efficient class‐switching of B cells to immunoglobulin (Ig)A in the germinal centres of PP. Thus, eosinophils are required to generate and to maintain mucosal IgA plasma cells, and as a consequence their absence leads to a marked reduction of IgA both in serum and in the gut‐associated lymphoid tissues (GALT). Eosinophils thus have an essential part in long‐term humoral immune protection, as they are crucial for the longevity of antibody‐producing plasma cells in the bone marrow and, in addition, for gut immune homeostasis.

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Section: Introductionmentioning

confidence: 99%

Eosinophils: important players in humoral immunity

Berek

2015

Clinical and Experimental Immunology

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“…55 In a recent study, Moqbel et al demonstrated in surgically removed thymus of neonates and children that eosinophils express IDO, IL-4, and IL-13; this expression was also shown to decrease with age. 56 They suggest that the IDO-positive eosinophils contribute to the Th2 character of the developing thymus in normal humans by inducing apoptosis of Th1 cells through depletion of tryptophan. An alternative function of eosinophils in the thymus was demonstrated recently by Kim et al that suggests eosinophils aid macrophages in the phagocytosis of apoptotic thymocytes induced by ␥-irradiation.…”

Section: Thymic Development and T-cell Selectionmentioning

confidence: 99%

“…56 The presence of eosinophils within the corticomedullary and medullary region have suggested that these cells may participate directly in the selection of T cells or may aid in the scavenging of dead cells that fail negative selection. Throsby et al characterized these mouse-derived eosinophils as CD11c int , CD11b hi , CD44 hi cells that express TGF-␤, IL-4, and IL-13 and are capable of acute class 1-dependent negative selection of T cells.…”

Section: Thymic Development and T-cell Selectionmentioning

confidence: 99%

The expanding role(s) of eosinophils in health and disease

Jacobsen¹,

Helmers

Lee³

et al. 2012

Blood

180

154

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Surprisingly, the role(s) of eosinophils in health and disease is often summarized by clinicians and basic research scientists as a pervasive consensus opinion first learned in medical/graduate school. Eosinophils are rare white blood cells whose activities are primarily destructive and are only relevant in parasitic infections and asthma. However, is this consensus correct? This review argues that the wealth of available studies investigating the role(s) of eosinophils in both health and disease demonstrates that the activities of these granulocytes are far more expansive and complex than previously appreciated. In turn, this greater understanding has led to the realization that eosinophils have significant contributory roles in a wide range of diseases. Furthermore, published studies even implicate eosinophil-mediated activities in otherwise healthy persons. We suggest that the collective reports in the literature showing a role for eosinophils in an everincreasing number of novel settings highlight the true complexity and importance of this granulocyte. Indeed, discussions of eosinophils are no longer simple and more often than not now begin with the question/statement "Did you know . . .?" (Blood. 2012;120(19):3882-3890)

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“…Measurements were taken in 10 randomly selected non-overlapping fields from the animals of each group (29) . All Morphometric measurements were taken at total magnification X1000.…”

Section: Iv-morphometric Studymentioning

confidence: 99%

Histological and Immunohistochemical Study on the Effect of Constant Light Exposure on T Lymphocyte Subsets in the Thymus and Lymph Node of Male Albino Rats

Rifaai

Baky

2017

Egyptian Journal of Histology

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Background: Today there is a widespread exposure to high levels of light at night. . This causes divergence from the natural environment and leads to significant implications on the circadian rhythm. Constant light exposure inhibits melatonin secretion and increases serum concentration of corticosterone. The immune system is very sensitive to stress. Aim of the Work: to study the effect of chronic exposure to constant light (as a model of stress) on the T lymphocytes populations and distribution in the thymus and lymph node. Material and Methods: animals were divided into two groups (10 rats each). The 1st group considered as control group, was kept on a day light-darkness for 12-12 h. The 2nd group was kept under complete artificial light for a period of 4 weeks. Thymus glands and the cervical lymph nodes of rats were removed and processed for haematoxylin and eosin, and immunohistochemical staining for CD3, CD4 and CD8. Results: lymphocytic depletion was noticed in the thymus and lymph nodes of the constant light exposed group. Also the distribution of CD3 and CD4 positive cells were altered in the lymph node of the same group. Conclusion: Constant light stress causes lymphocytic depletion and alters lymphoid cell subsets distribution both in the thymus and lymph nodes.

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Thymic Indoleamine 2,3-Dioxygenase-Positive Eosinophils in Young Children

Cited by 37 publications

References 38 publications

Eosinophils: important players in humoral immunity

Eosinophils: important players in humoral immunity

The expanding role(s) of eosinophils in health and disease

Histological and Immunohistochemical Study on the Effect of Constant Light Exposure on T Lymphocyte Subsets in the Thymus and Lymph Node of Male Albino Rats

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