Thymic hyperplasia in a patient with Grave's disease

Hamzaoui, A.; Klii, R.; Salem, R.; Kochtali, I.; Golli, M.; Mahjoub, S.

doi:10.1186/1755-7682-5-6

Cited by 8 publications

(7 citation statements)

References 15 publications

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“…In addition to the 92 cases discussed by Deforges-Bullet et al [9], we found another 15 case reports of thymic enlargements associated with GD published to date [12][13][14][15][16][17][18][19][20][21][22]. Only 4 of these 107 cases in all were diagnosed as thymic malignancies (three thymomas and one T lymphoblastic lymphoma/leukemia [19][20][21]), while TH was confirmed in all the other cases.…”

Section: Review Of the Literaturesupporting

confidence: 42%

“…When TH is diagnosed in association with GD, in the absence of myasthenia gravis and/or suspect CT findings [16], it can generally be considered a benign condition, in which case only antithyroid treatment and radiological follow-up are warranted. The time to remission of TH under medical treatment varies considerably (from 2 to 24 months) and is impossible to predict before starting the therapy [35].…”

Section: Resultsmentioning

confidence: 99%

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Thymic hyperplasia in patients with Graves’ disease

Costa

Mangano²,

Betterle

2014

J Endocrinol Invest

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Section: Review Of the Literaturesupporting

confidence: 42%

Section: Resultsmentioning

confidence: 99%

Thymic hyperplasia in patients with Graves’ disease

Costa

Mangano²,

Betterle

2014

J Endocrinol Invest

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“…However, many hyperplasia cases presented with large soft tissue masses, which were easily detected on chest radiograph, were found misdiagnosed as thymoma. 9 -13 In patients with MG, Nicolaou et al 14 found thymic lymphoid hyperplasia can exhibit variable morphologies and sizes as it may appear normal (45% of cases), triangular-shaped diffusely enlargement with smooth margin (35%), or as a focal thymic mass (20%). This mass could not be differentiated with thymoma (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

The Value of CT and MRI for Determining Thymoma in Patients With Myasthenia Gravis

Tuấn¹,

Viện²,

Dong

et al. 2019

Cancer Control

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The aim of the study was to evaluate the usefulness of computed tomography (CT) and magnetic resonance imaging (MRI) for differentiating thymoma from nonthymoma abnormalities in patients with myasthenia gravis (MG). A cross-sectional study of 53 patients with MG, who had undergone surgical thymectomy, was conducted at 103 Hospital (Hanoi, Vietnam) and Cho Ray Hospital (Ho Chi Minh City, Vietnam) during August 2014 and January 2017. The CT and MRI images of patients with MG were qualitatively and quantitatively (radiodensity and chemical shift ratio [CSR]) analyzed to determine and compare their ability to distinguish thymoma from nonthymoma abnormalities. Logistic regression was used to identify the association between imaging parameters (eg, CSR) and the thymoma status. The receiver operating curve (ROC) analysis was used to determine the differentiating ability of CSR and radiodensity. As results, of the 53 patients with MG, 33 were with thymoma and 20 were with nonthymoma abnormalities. At qualitative assessment, MRI had significantly higher accuracy than did CT in differentiating thymoma from nonthymoma abnormalities (94.3% vs 83%). At quantitative assessment, both the radiodensity and CSR were significantly higher for thymoma compared with nonthymoma groups ( P < .001). The ROC analysis showed that CSR had significantly higher sensitivity (Se) and specificity (Sp) than radiodensity in discriminating between the 2 groups (CSR: Se 100%, Sp 95% vs radiodensity: Se 90.9%, Sp 70%). When combining both qualitative and quantitative parameters, MRI had even higher accuracy than did CT in thymoma diagnosis ( P = .031). In conclusion, chemical shift MRI was more accurate than CT for differentiating thymoma from nonthymoma in patients with MG.

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“…These autoantibodies have a stimulating effect on the thyroid gland. The incidence of the disease in the population is 16 women and 3 men per 100 000 inhabitants / year [4].…”

Section: Discussionmentioning

confidence: 99%

Bilateral exorbitism revealing thymic hyperplasia: Case report and review of the literature

Bellamlih¹

2018

Int J Case Rep Images

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Introduction:Graves' thyroiditis is an autoimmune disease, commonly associated with other autoimmune disorders, such as myasthenia gravis, autoimmune gastritis, Type 1 diabetes, vitiligo, and Addison's disease. There is a welldocumented association between Graves' disease and thymus hyperplasia. The knowledge of this association makes it possible to avoid a risky and unnecessary surgery of a thymus mass in patients with Graves' disease. Case Report: We report the case of a patient with bilateral exophthalmos. The biological and radiological assessment was in favor of a grave disease associated with thymus hyperplasia. A medical treatment was administered with a favorable evolution. There were no sign of malignancy in the follow up exam. Conclusion: Knowledge of the association between Graves' disease and thymus hyperplasia is necessary. For there is some authors that preconize thymus surgery in cases of resistant grave disease. The favorable evolution under medical treatment makes it possible to avoid unnecessary, even dangerous, thymus mass surgery in patients with Graves' disease by proposing a simple radiological monitoring.

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Thymic hyperplasia in a patient with Grave's disease

Abstract: Hyperplastic changes of the thymus may be found in patients with Graves' disease. However, this rarely presents as an anterior mediastinal mass, particularly among adults. In this report, we describe a 46-year old woman with Graves' disease and thymic hyperplasia.

Cited by 8 publications

References 15 publications

Thymic hyperplasia in patients with Graves’ disease

Thymic hyperplasia in patients with Graves’ disease

The Value of CT and MRI for Determining Thymoma in Patients With Myasthenia Gravis

Bilateral exorbitism revealing thymic hyperplasia: Case report and review of the literature

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