Thymic epithelial tumours: A population-based study of the incidence, diagnostic procedures and therapy

Jong, Wouter K. de; Blaauwgeers, J. L. G.; Schaapveld, Michael; Timens, Wim; Klinkenberg, Theo J.; Groen, Harry J.M.

doi:10.1016/j.ejca.2007.11.004

Cited by 235 publications

(180 citation statements)

References 27 publications

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“…Table 1 provides a list of the various reported subtypes as defined by the 1999/2004 WHO classification system where known. From this, it appears that the general distribution parallels that of mediastinal thymomas, where type AB thymomas represent one of the more common subtypes [26]. One interesting observation is the marked female predominance in ECT [3], which differs from the demographics of the mediastinal thymomas where there is only a slight female predominance [26].…”

Section: Discussionmentioning

confidence: 81%

Ectopic Cervical Thymoma: A Report of Two Cases of a Rare Entity Frequently Misdiagnosed on Fine Needle Aspiration Cytology and Frozen Section

Yan

Lim

Petersson

2010

Head and Neck Pathol

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Ectopic cervical thymoma (ECT) is a rare tumor that is frequently misdiagnosed on fine needle aspiration cytology and frozen section. Using conventional light microscopy and immunohistochemistry, we characterized the only two cases of ECT found in our institutional files over a period of 20 years. Both tumors were classified as type AB-thymoma. Neoplastic cells expressed cytokeratins but not CD5. Non-neoplastic T-lymphocytes were positive for CD3 and CD5. Lymphocytes expressed CD1a in only one case. One tumor breached the capsule and had positive surgical margins. For this patient, adjuvant radiotherapy was given. The other patient has had an uneventful follow-up for 20 years with no other therapy than surgery. Both cases of ECT showed identical histomorphological and immunohistochemical features of type AB-thymomas originating in the thymus. Short follow-up precludes conclusion on the implication of positive margins in conjunction with adjuvant radiotherapy for one of the patients presented herein.

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Section: Discussionmentioning

confidence: 81%

Ectopic Cervical Thymoma: A Report of Two Cases of a Rare Entity Frequently Misdiagnosed on Fine Needle Aspiration Cytology and Frozen Section

Yan

Lim

Petersson

2010

Head and Neck Pathol

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“…The incidence for thymomas ranges between 1.3 and 2.5 per million per year. [1][2][3] Thymic carcinomas are even less frequent. Thymic epithelial tumors have been reported at any age but occur most commonly at 40 to 60 years of age, and are extremely rare in children.…”

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confidence: 99%

Evolution of Classification of Thymic Epithelial Tumors in the Era of Dr Thomas V. Colby

Roden¹

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Numerous histomorphologic and staging classifications of thymic epithelial tumors (TETs) have been proposed during the last century, suggesting that the classification of these tumors is challenging and controversial. Difficulties of classifying TETs include various combinations of epithelial cells and lymphocytes and the paucity of these tumors. The prognostic significance, specifically of the histomorphologic classifications, has been debated. Early classifications were also challenged by the uncertainty of the neoplastic component(s) of the tumor.Objective.-To discuss the evolution of the histomorphologic classification and the staging system of TET. Controversies and problems of some classifications and their importance for therapeutic management and prognosis will be reviewed. Classifications that incorporated new concepts and approaches at the time or outcome studies will be highlighted. Current classifications will be discussed and the staging system that was recently proposed for the upcoming eighth American Joint Committee on Cancer staging will be described.Data Sources.-Search of literature database (PubMed) and current (2015) World Health Organization classification.Conclusions.-Histomorphologic and staging classifications of TET have evolved during the last century and especially during the era of Thomas V. Colby, MD. Evidence supports that the staging system has prognostic implications independent of and superior to the histomorphologic classification. Histomorphology appears to be important for biologic features of TET.

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“…MG-assoziierte Fälle haben eine bessere Prognose, möglicher-weise weil sie früher entdeckt werden [3].…”

Section: Prognoseunclassified

Thymome

2016

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Thymic epithelial tumours: A population-based study of the incidence, diagnostic procedures and therapy

Cited by 235 publications

References 27 publications

Ectopic Cervical Thymoma: A Report of Two Cases of a Rare Entity Frequently Misdiagnosed on Fine Needle Aspiration Cytology and Frozen Section

Ectopic Cervical Thymoma: A Report of Two Cases of a Rare Entity Frequently Misdiagnosed on Fine Needle Aspiration Cytology and Frozen Section

Evolution of Classification of Thymic Epithelial Tumors in the Era of Dr Thomas V. Colby

Thymome

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