Thymic Determinants of γδ T Cell Differentiation

Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection

“…Early seminal discoveries demonstrated that the first murine γδ T cells produced by the thymus during early development have canonical TCRs lacking N additions, including an invariant δ chain (43,44). It is believed that these T cells then migrate to distinctive sites within the body dictated by the TCR-γ chain they express (33,45). The TRGV5 gene rearrangement detected in our study corresponds to that reported for the previously described invariant Vγ5 + dendritic epidermal T cells (DETCs) (43,44).…”

“…DETCs are the most common skin-resident γδ T cell population and have been reported to recognize a stress-induced self-antigen derived from keratinocytes (46,47). In contrast, the TRGV6 gene rearrangement described herein corresponds to that reported for canonical γδ T cells residing in the liver, placenta, kidney, uterus, tongue and other mucosal sites (33,45). Interestingly, the dominant TRDV4 gene rearrangement that was found in both the skin and LNs encodes the same CDR3 aa sequence for the Vδ1 chain of DETCs and was previously reported to only be present in remodeling epithelial tissues such as the placenta and lactating mammary glands (48,49).…”

γδ T cells in cancer: a small population of lymphocytes with big implications

“…1 Although cd T cells make up only a minor proportion of the CD3 + compartment in the circulation and most tissues, because of their rapid cytokine production following activation, they constitute an important first line of defence against infections and are important players in antitumor defence. [4][5][6] Unlike ab T cells, activation of cd T cells through their TCR is generally thought not to be restricted to presentation of peptide by MHC molecules, although a human cd T-cell clone capable of recognising melanoma tumor antigens MART-1 and gp100 in a MHC I-restricted fashion was recently generated in an artificial experimental system. Despite their well-documented innate properties, the adaptive features of cd T cells are also essential in their development and function.…”

The natural history of naive T cells from birth to maturity

“…In contrast to DN4 thymocytes, γδ T cells do not undergo a burst of division and several distinct lineages of γδ T cells emerge during ontogeny, defined by cytokine‐producing potential. IL‐17‐secreting dendritic epidermal γδ T cells, that reside in the epidermis of the skin, are known to develop as a distinct wave only in the fetal period . In contrast, undifferentiated and interferon‐producing γδ T cells appear to develop in the thymus throughout life .…”

“…IL‐17‐secreting dendritic epidermal γδ T cells, that reside in the epidermis of the skin, are known to develop as a distinct wave only in the fetal period . In contrast, undifferentiated and interferon‐producing γδ T cells appear to develop in the thymus throughout life . However, it is unclear what role this population has in the production and maintenance of peripheral γδ T cells.…”