2003
DOI: 10.4049/jimmunol.171.9.4927
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Thymic CD8+ T Cell Production Strongly Influences Tumor Antigen Recognition and Age-Dependent Glioma Mortality

Abstract: For unknown reasons, advanced age remains a dominant predictor of poor clinical outcome for nearly all cancers. A decrease in the production of T cells by the thymus accompanies normal aging and parallels the age-dependent increase in cancer progression, but the specific impact of immunity on tumor progression in general is unknown. Glioblastoma multiforme (GBM), the most common primary brain neoplasm, is characterized by rapid age-dependent rates of progression and death. In this study, we show levels of CD8+… Show more

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Cited by 78 publications
(70 citation statements)
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“…Old mice with an average age of approximately P600 have significantly less CD8 ϩ T-cells compared with animals of ϳP300, resulting in decreased survival to experimental glioblastomas (Wheeler et al, 2003). However, in the age groups compared in the present study, these immune effects are not likely to be preponderant.…”
Section: Discussioncontrasting
confidence: 43%
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“…Old mice with an average age of approximately P600 have significantly less CD8 ϩ T-cells compared with animals of ϳP300, resulting in decreased survival to experimental glioblastomas (Wheeler et al, 2003). However, in the age groups compared in the present study, these immune effects are not likely to be preponderant.…”
Section: Discussioncontrasting
confidence: 43%
“…The highly invasive phenotype of these tumor cells has been established previously (Westermark et al, 1973;Ponten and Westermark, 1978;Arnhold et al, 2003;Wheeler et al, 2003). We verified that G261 cells kept their glioblastoma phenotype in vitro and in vivo.…”
Section: Characterization Of the Glioblastoma Modelmentioning
confidence: 58%
“…Also for malignant brain tumour, MHC class I-associated peptides have been eluted from cultured autologous glioma cells, and a mixture of peptides was used to load DC since no specific tumour antigenic targets are known (Yu et al, 2001). In other trials, tumour proteins instead of peptides have been used to load DC (Hsu et al, 1996;Schott et al, 2000;Geiger et al, 2001;Chang et al, 2002;Höltl et al, 2002;Wheeler et al, 2003;Yamanaka et al, 2003;De Vleeschouwer et al, 2004). The use of proteins from autologous tumours instead of peptides is now generally considered a valuable approach, certainly when tumour-specific epitopes are not known (Curiel and Curiel, 2002).…”
Section: Discussionmentioning
confidence: 99%
“…Vaccination might induce better survivals in younger patients, in whom complete resection of malignant glioma can be reached more frequently. Moreover, the cytogenetic entity of malignant glioma at younger age differs from adult malignant glioma (Kraus et al, 2002) and might also be responsible for different immunological targeting, besides the differences in immune competence at younger age (Wheeler et al, 2003). To further implement these issues, the ongoing HGG-IMMUNO-2003 trial of our group includes patients below the age of 60 years with at least subtotal resection of the relapsed tumour.…”
Section: Discussionmentioning
confidence: 99%
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