Thymic alterations in Plasmodium berghei-infected mice

Thymic microenvironmental alterations in experimentally induced diabetes

“…npr0.05, nnpr0.01 and nnnpr0.001. diseases, mainly infectious diseases (Savino, 2006;Andrade et al, 2008). In other experimental diabetes models, similar results were also found (Barreto et al, 2005;Elmas et al, 2008).…”

Acute Thymic Involution and Mechanisms for Recovery

“…In this infection, ATI was a primary event, and alteration in the histological structure of the thymus and a significant decrease (nearly 50-fold) in the numbers of DP thymocytes were observed during the course of infection (Andrade et al 2008). Similar morphological changes were also observed in another study of an experimental mouse infection with P. berghei.…”

“…TNF-α signaling pathway Pentoxifylline administration Andrade et al 2008;Francelin et al 2011;Keswani and Bhattacharyya 2013;Khanam et al 2015;Lima et al 2012 Fungus…”

Effects of Plasmodium berghei on thymus: High levels of apoptosis and premature egress of CD4+CD8+ thymocytes in experimentally infected mice

“…Acute thymic atrophy observed during infections is accompanied by the loss of the maintenance of thymic microenvironment and abnormal development of thymocytes (Savino et al 1986;Sodora et al 2002;Brito et al 2003;Souto et al 2003;Savino 2006;Seixas and Ostler 2005;Cotta-de-Almeida et al 2003;Andrade et al 2008).…”

“…Previously, using a lethal murine malaria model of Plasmodium berghei, we have also shown profound histological alterations and severe thymic atrophy with loss of DP cells. In addition, the presence of parasites inside the thymus was detected for the first time (Andrade et al 2008). In another study that used the same model, we have demonstrated changes in the expression of extracellular matrix elements and chemokine protein families in Plasmodiuminfected animals (Gameiro et al 2009).…”