Thymectomy and Chronic Relapsing Experimental Allergic Encephalomyelitis in Guinea Pigs

Flechter, Shlomo; Vardi, Jacob; Just, Israel; Arnon, Ruth; Teitelbaum, Dvora

doi:10.1001/archneur.1984.04050220052014

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…If the association between MS and MG is true it is quite possible that thymectomy may be of value for MS. [19] MS patients with undue fatigue or fluctuating features should be investigated for MG. Awareness of this possible association would lead to early diagnosis of ocular MG as the ocular manifestation are more common in patients with MS and MG.…”

Section: Discussionmentioning

confidence: 99%

Frequency of myasthenia gravis in multiple sclerosis: Report of five cases from Isfahan, Iran

et al. 2009

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This study was designed to determine the frequency and clinical characteristics of myasthenia gravis (MG) in a large cohort of Persian patients with multiple sclerosis (MS) living in the province of Isfahan. We reviewed the case records of patients with definite MS (McDonald's criteria) registered in the Isfahan MS Society (IMSS) for associated MG. Of the 1,718 patients with MS in the registry, six patients were found to have both MS and MG. The prevalence after excluding one patient with insufficient data, was 291 per 100,000 (0.29%), a higher prevalence than the earlier reports. These results may support the hypothesis that MS and MG share some common immunopathogenic mechanisms.

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Section: Discussionmentioning

confidence: 99%

Frequency of myasthenia gravis in multiple sclerosis: Report of five cases from Isfahan, Iran

et al. 2009

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“…Previous work has demonstrated that thymectomy in newborn mice prevented or markedly delayed the appearance of EAE symptoms ( 21 , 22 ), suggesting that T cells are required for the production of signs and histological lesions. Also, MS patients were shown to present decreased thymic output ( 23 ), indicating that the thymic function could be altered in the disease.…”

Section: Introductionmentioning

confidence: 99%

Immune Thymic Profile of the MOG-Induced Experimental Autoimmune Encephalomyelitis Mouse Model

et al. 2018

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Multiple sclerosis (MS) is a chronic, immune-mediated, demyelinating disease that affects the neurons of the central nervous system. Activated T cells, specific for myelin epitopes, cross the brain barriers, and react against the myelin sheath, leading to demyelination. Since T cells are generated within the thymus, here we explored, in mice, the alterations occurring in this organ throughout the different phases of the disease. We induced experimental autoimmune encephalomyelitis (EAE) in C57BL/6 females and sacrifice them at the onset (day 16) and chronic phases of disease (day 23), along with non-induced controls. We observed thymic atrophy in EAE mice at the onset that remained until the chronic phase of disease. This atrophy was associated with a preferential loss of the CD4+CD8+ double positive thymocytes, an intermediate population between the more immature CD4−CD8− double negative and the most mature single positive thymocytes. This was accompanied by an increase in the thymic medullary/cortical ratio and by an altered expression levels of genes important for T cell survival. During the chronic phase, the thymi remained atrophic, but reacquired the normal proportion of the main four thymocyte populations and the normal medullary/cortical ratio. Importantly, at the onset phase, and accompanying these thymic alterations, EAE animals presented an increased percentage of demyelinating lesion area in the cerebellum, and an increased expression of interferon gamma (Ifng), interleukin (Il) 12a, and Il17a. This study suggests dynamic thymic alterations occurring in response to EAE, from the induction to the chronic phase, that might help to elucidate the MS pathophysiology.

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Thymectomy and Chronic Relapsing Experimental Allergic Encephalomyelitis in Guinea Pigs

Cited by 2 publications

References 18 publications

Frequency of myasthenia gravis in multiple sclerosis: Report of five cases from Isfahan, Iran

Frequency of myasthenia gravis in multiple sclerosis: Report of five cases from Isfahan, Iran

Immune Thymic Profile of the MOG-Induced Experimental Autoimmune Encephalomyelitis Mouse Model

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