Thyme Leaves Aqueous Extract and its Formulations. A comparative study based on chemical structures and biological activity

Abstract

The present study was conducted in order to evaluate the biological activity of thyme aqueous extract as compared to the silver nanoparticles obtained on it on four different cancer lines: non-melanoma skin cancer (A431 cell line), melanoma skin cancer (A375cell line), hormone dependent breast cancer (MCF-7 cell line), and non-hormone dependent breast cancer (MDA-MB-231 cell line). Of particular importance in the study of biological activity is the chemical composition. Formulas rich in compounds of classes like those of flavonoids are recognized for their efficacy and important antioxidant effect. The extract tested at various concentrations ranging from 10-1000 �g/mL exhibited a pronounced effect only on MCF-7 cells at the highest concentration tested and regarding the biosynthesized silver nanoparticles, the effect can be noted even at 1 � M also only in the case of MCF-7 cells.

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“…The antibacterial potential of thyme is well recognized and documented; recently, Cheurfa and Allem [433] tested [434] obtaining excellent results as the extract of this herb had a high antiglycation effect with 50 % inhibitory concentration (IC 50 ) of 0.02 mg/mL. As already stated for essential oils (see previous paragraphs), the use of nanoconstructs can modulate and even ameliorate the bioactivities of vegetable matrices; Proks et al [435] conducted an experiment on four different cancer cell lines: (12), quercetin (30) and phloridzin (54). As regarding uncommon thyme varieties, Khouya and others [436] evaluated the anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Thymus atlanticus, T. satureioides and T. zygis.…”

“…The antidiabetic effect measured as in vitro antiglycation activity (ability of the extracts to inhibit the methyl glyoxal mediated development of fluorescence of bovine serum albumin BSA) of a 80 % acetone extract from Thymus vulgaris (thyme) was studied by Kazeem and others obtaining excellent results as the extract of this herb had a high antiglycation effect with 50 % inhibitory concentration (IC 50 ) of 0.02 mg/mL. As already stated for essential oils (see previous paragraphs), the use of nano‐constructs can modulate and even ameliorate the bioactivities of vegetable matrices; Proks et al . conducted an experiment on four different cancer cell lines: non‐melanoma skin cancer (A431 cell line), melanoma skin cancer (A375 cell line), hormone dependent breast cancer (MCF‐7 cell line) and non‐hormone dependent breast cancer (MDA‐MB‐231 cell line).…”