Thwarting protein synthesis leads to malaria parasite paralysis

Medicinal polypharmacology: Exploration and exploitation of the polypharmacolome in modern drug development

“…Modern systems biology and network pharmacology analyses steadily reveal important puzzle pieces of a “big picture” of complex diseases (Jamir et al, 2023; Olson et al, 2023) which allows for the conclusion that biological effects of small‐molecule therapeutics in the human body result from multiple individual interactions with multiple targets (Anighoro et al, 2014; Jalencas & Mestres, 2013a; Paolini et al, 2006; Schmidt et al, 2014; Vulpetti et al, 2012). Today, modern drugs should intentionally engage multiple targets to overcome disease and/or therapy resistance (Hopkins, 2008; Jamir et al, 2023; McKie, 2016; Mogwera et al, 2023; Proschak et al, 2019; Zimmermann et al, 2007) to provide additive or even synergistic effects (Anighoro et al, 2014; Azmi & Mohammad, 2014; Proschak et al, 2019). This becomes evident considering the multifactority of many prevalent human diseases that can barely be addressed by single‐targeted approaches.…”