Thumb-Sucking, Nail-Biting, and Atopic Sensitization, Asthma, and Hay Fever

Lynch, Stephanie J; Sears, Malcolm R.; Hancox, Robert J.

doi:10.1542/peds.2016-0443

Cited by 21 publications

(12 citation statements)

References 31 publications

(32 reference statements)

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“…The relationship between gestational smoke exposure and childhood asthma development is well documented and presents a major health problem for generations to come (3,(7)(8)(9)(10)(11)35). Only few follow-up studies have examined gene-environmental interactions on adult onset of asthma (36,37). A study, in which parental smoking exposure was assessed retrospectively by a questionnaire to adult offspring, has documented that both intrauterine exposure to maternal smoking during pregnancy and postnatal exposure to environmental tobacco smoke adversely affected adult lung function and increased risk for adult-onset asthma (12).…”

Section: Discussionmentioning

confidence: 99%

Maternal smoking during pregnancy affects adult onset of asthma in offspring: a follow up from birth to age 46 years

Toppila‐Salmi

Luukkainen

et al. 2020

Eur Respir J

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RationaleEnvironmental tobacco smoke (ETS) exposure increases asthma risk in children. There is limited knowledge of prenatal ETS for adult-onset asthma.ObjectivesTo determine the association between prenatal ETS and adult onset asthma.Measurements and main resultsThe questionnaire and clinical data of 5200 people, free of physician-diagnosed asthma by 31 years of age, who were included in the Northern Finland Birth Cohort 1966 Study was used. The association of maternal smoking during the last 3 months of pregnancy with onset of physician-diagnosed asthma and with lung function in adult offspring was studied using adjusted multivariate regression analyses. The cumulative incidence of physician-diagnosed asthma between the ages of 31 and 46 years was 5.1% among men and 8.8% among women. Gestational smoke exposure was associated with adult-onset asthma among offspring (adjusted OR 1.54, 95% CI 1.04–2.29), namely among offspring who reported either past non-diagnosed asthma (OR 9.63, 95% CI 2.28–40.67) or past cough with wheeze (3.21, 95% CI 1.71–6.05). A significant association was detected between gestational smoke exposure and the offspring's forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio at 31 years of age. In offspring with the haplotype rs11702779-AA of RUNX1, gestational smoke exposure was associated with adult-onset asthma (5.53, 95% CI 2.11–14.52, adjusted p-value for interaction 0.10).ConclusionMaternal smoking during pregnancy is associated with the cumulative incidence of asthma in offspring between the ages of 31 and 46 years. The association was accentuated in offspring who at age 31, reported having past respiratory problems and/or who had haplotype rs11702779-AA. A reduction in FEV1/FVC ratio was also observed at age 31 years in offspring with gestational smoke exposure. These results could reflect the early vulnerability of offspring's airways to ETS and its putative long-term effects.

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Section: Discussionmentioning

confidence: 99%

Maternal smoking during pregnancy affects adult onset of asthma in offspring: a follow up from birth to age 46 years

Toppila‐Salmi

Luukkainen

et al. 2020

Eur Respir J

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“…Nevertheless, we may have overshot the mark with our attempts to reduce the risk of pathogen exposure. Therefore, we should seek a more moderate attitude that facilitates exposure of our children to benign nonpathogenic microorganisms (91). The first attempts, such as exposure to maternal vaginal fluid after caesarean section or the administration of probiotic bacteria to preterm neonates, are being made (25,92,93).…”

Section: Discussionmentioning

confidence: 99%

The Neonatal Window of Opportunity: Setting the Stage for Life-Long Host-Microbial Interaction and Immune Homeostasis

Torow

Hornef

2017

The Journal of Immunology

161

105

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The existence of a neonatal window was first highlighted by epidemiological studies that revealed the particular importance of this early time in life for the susceptibility to immune-mediated diseases in humans. Recently, the first animal studies emerged that present examples of early-life exposure-triggered persisting immune events, allowing a detailed analysis of the factors that define this particular time period. The enteric microbiota and the innate and adaptive immune system represent prime candidates that impact on the pathogenesis of immune-mediated diseases and are known to reach a lasting homeostatic equilibrium following a dynamic priming period after birth. In this review, we outline the postnatal establishment of the microbiota and maturation of the innate and adaptive immune system and discuss examples of early-life exposure-triggered immune-mediated diseases that start to shed light on the critical importance of the early postnatal period for life-long immune homeostasis.

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“…Various evidence is consistent with the hygiene hypothesis in relation to allergies and autoimmune disorders. Children who sucked their thumbs or bit their nails have been shown to develop less atopic sensitization ( Lynch et al., 2016 ). Children who were born vaginally or whose parents sucked their pacifiers to clean them have less allergy, asthma, and/or eczema ( Hesselmar et al., 2013 ).…”

Section: Behavior Mood and The Immune Responsementioning

confidence: 99%

Immune dysregulation in depression: Evidence from genome-wide association

Tubbs

Ding

Baum

et al. 2020

Brain, Behavior, & Immunity - Health

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A strong body of evidence supports a role for immune dysregulation across many psychiatric disorders including depression, the leading cause of global disability. Recent progress in the search for genetic variants associated with depression provides the opportunity to strengthen our current understanding of etiological factors contributing to depression and generate novel hypotheses. Here, we provide an overview of the literature demonstrating a role for immune dysregulation in depression, followed by a detailed discussion of the immune-related genes identified by the most recent genome-wide meta-analysis of depression. These genes represent strong evidence-based targets for future basic and translational research which aims to understand the role of the immune system in depression pathology and identify novel points for therapeutic intervention.

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Thumb-Sucking, Nail-Biting, and Atopic Sensitization, Asthma, and Hay Fever

Cited by 21 publications

References 31 publications

Maternal smoking during pregnancy affects adult onset of asthma in offspring: a follow up from birth to age 46 years

Maternal smoking during pregnancy affects adult onset of asthma in offspring: a follow up from birth to age 46 years

The Neonatal Window of Opportunity: Setting the Stage for Life-Long Host-Microbial Interaction and Immune Homeostasis

Immune dysregulation in depression: Evidence from genome-wide association

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