Thumb Infection Caused by
 Streptococcus pseudoporcinus

Mahlen, Steven D.; Clarridge, Jill E.

doi:10.1128/jcm.00802-09

Cited by 18 publications

(23 citation statements)

References 13 publications

(14 reference statements)

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“…The pathogenicity of S. pseudoporcinus remains unknown, except for causing obstetric disorders such as chorioamnionitis and preterm delivery (6,7). Previous report described skin infections related with by S. pseudoporcinus is only a few, so far (8). To our knowledge, this is the first case of cellulitis caused by S. pseudoporcinus.…”

Section: Introductionmentioning

confidence: 69%

A case of leg cellulitis caused by multidrug-resistant Streptococcus pseudoporcinus

Sawamura

Niimori

Ihn

2018

IRDR

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Section: Introductionmentioning

confidence: 69%

A case of leg cellulitis caused by multidrug-resistant Streptococcus pseudoporcinus

Sawamura

Niimori

Ihn

2018

IRDR

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“…Outside vaginal colonization and genitourinary infections in pregnant women, to date, only a case report of a thumb infection caused by S. pseudoporcinus has been reported in the literature (10). In our study, we recovered S. pseudoporcinus from a surgical wound that contained mixed pathogens and from the urine of a symptomatic patient who also had an E. coli UTI.…”

mentioning

confidence: 71%

“…With the manufacturer's cutoff score of 2, MALDI-TOF MS was able to reidentify all (100%) of the S. pseudoporcinus isolates (data not shown). As expected, the BD MAX GBS assay is very specific for the detection of S. agalactiae (10) and no false-positive results with S. pseudoporcinus isolates were seen in our limited testing. Although the prevalence of S. pseudoporcinus colonization of women in our hospital was low, we found a higher rate of clindamycin and erythromycin resistance (18% for both) than in previous studies (0 to 3%) ( Table 3) (2-4).…”

mentioning

confidence: 72%

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Recognition of Streptococcuspseudoporcinus Colonization in Women as a Consequence of Using Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry for Group B Streptococcus Identification

et al. 2015

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dDuring a 14-month period of using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) for group B streptococcus (GBS) identification, we recovered 32 (1%) Streptococcus pseudoporcinus isolates from 3,276 GBS screening cultures from female genital sources (25 isolates from pregnant women and 7 from nonpregnant women). An additional two S. pseudoporcinus isolates were identified from a urine culture and a posthysterectomy wound culture. These isolates were found to cross-react with three different GBS antigen agglutination kits, PathoDx (Remel) (93%), Prolex (Pro-Lab Diagnostics) (38%), and Streptex (Remel) (53%). New approaches to bacterial identification in routine clinical microbiology laboratories may affect the prevalence of S. pseudoporcinus. Streptococcus pseudoporcinus is a beta-hemolytic Gram-positive coccus that was identified as a separate and independent Streptococcus species in 2006 (1). S. pseudoporcinus has been isolated from the female genitourinary tract and has biochemical characteristics similar to those of Streptococcus agalactiae, which is also known as group B streptococcus (GBS) (1-3). The prevalence and clinical significance of genitourinary S. pseudoporcinus and its relationship to peripartum neonatal and maternal infections are not currently known (2, 3). In 2011, Stoner et al. (4) sought to identify the prevalence and epidemiology of S. pseudoporcinus in the genital tracts of nonpregnant women. They found that 5.4% of the women in their study had genital cultures positive for this bacterium. The cross-reactivity of standard GBS testing kits raises concerns that S. pseudoporcinus has been misidentified as GBS in routine GBS screening cultures (1-4). In addition, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis is coming to be routinely used for organism identification (5, 6). At the Johns Hopkins Hospital (JHH) microbiology laboratory, we became aware of S. pseudoporcinus identification from positive GBS screening cultures after the implementation of MALDI-TOF MS (Bruker Daltonics, Billerica, MA) for organism identification. Thus, we prospectively identified S. pseudoporcinus isolates from GBS screening cultures to determine the prevalence and clinical characteristics of patients with S. pseudoporcinus colonization.(Some of the data in this paper were presented in poster form at the 115th General Meeting of the American Society for Microbiology, 30 May to 2 June 2015, New Orleans, LA.)We identified S. pseudoporcinus and S. agalactiae from GBS screening cultures at the JHH between 1 April 2014 and 31 May 2015. Swabs from female genital sources were inoculated into Todd-Hewitt (TH) broth and onto 5% sheep blood agar (SBA; Remel, Lenexa, KS) plates. The broth was incubated at 35°C in a 5% CO 2 incubator for 18 to 24 h, subcultured onto 5% SBA, and then incubated for 18 to 24 h. Beta-hemolytic colonies from GBS screening cultures were identified by MALDI-TOF MS (Bruker Microflex, Biotyper software V.3...

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“…Although it was phenotypically identified as Streptococcus porcinus, sequencing data differentiated it as a novel species [1]. Only two reported human infections implicated this bacterium including a wound infection of a finger as a result of trauma and another with left lower leg cellulitis associated with stasis dermatitis [2,3]. We describe two additional cases, one causing endocarditis and a second with pneumonia and empyema.…”

Section: Introductionmentioning

confidence: 87%

Streptococcus pseudoporcinus: Case Reports and Review of the Literature

Khan

Wong

Prasad

et al. 2020

Case Reports in Infectious Diseases

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Streptococcus pseudoporcinus is a beta-hemolytic Gram-positive, catalase-negative, nonmotile coccus arranged in short chains, usually found in the female genitourinary tract and differentiated from Streptococcus porcinus in 2006. Only two human infections associated with this organism have been reported to date: one in a patient with a first digit wound infection and another with lower extremity cellulitis. We describe two novel cases of Streptococcus pseudoporcinus causing endocarditis in one and pneumonia with empyema in another, illustrating the potential of these bacteria to cause severe invasive and life-threatening disease.

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Thumb Infection Caused by Streptococcus pseudoporcinus

Abstract: Streptococcus pseudoporcinus , a recently described organism found in the genitourinary tract of women, was isolated from a thumb wound in a male patient subsequent to trauma. This case describes a rarely reported non-genitourinary tract clinical isolate of S. pseudoporcinus .

Cited by 18 publications

References 13 publications

A case of leg cellulitis caused by multidrug-resistant <i>Streptococcus pseudoporcinus </i>

A case of leg cellulitis caused by multidrug-resistant <i>Streptococcus pseudoporcinus </i>

Recognition of Streptococcuspseudoporcinus Colonization in Women as a Consequence of Using Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry for Group B Streptococcus Identification

Streptococcus pseudoporcinus: Case Reports and Review of the Literature

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