Thuja occidentalis L. and its active compound, α-thujone: Promising effects in the treatment of polycystic ovary syndrome without inducing osteoporosis

Akkol, Esra Küpeli; İlhan, Mert; Demırel, Mürşide Ayşe; Keleş, Hikmet; Tümen, İbrahim; Süntar, İpek

doi:10.1016/j.jep.2015.03.029

Cited by 38 publications

(22 citation statements)

References 20 publications

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“…Most of the oil contained cones of 'Brabant' variety (1.50%). According to the literature data, the content of the essential oil in T. occidentalis fresh leaves varied between 0.35% [13] to 0.82% [7]. Present study shows that 'Brabant' variety of T. occidentalis is much richer in essential oil than previously described plants of this species.…”

Section: Resultssupporting

confidence: 47%

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Comparison of chemical composition of the essential oils from different parts of Thuja occidentalis L. ‘Brabant’ and T. occidentalis L. ‘Smaragd’

2016

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S u m m a r yIntroduction: Thuja occidentalis 'Brabant' and T. occidentalis 'Smaragd' are widely planted as decoration in parks and as hedges in domestic gardens in Poland. Objective: The aim of the study was to determine the yield and the composition of essential oils from different parts of these cultivars. Methods: The essential oils were obtained by hydrodistillation, and then analyzed by GC/MS. Results: Over seventy compounds were identified. The oils from leaves, twigs with leaves and twigs without leaves of 'Brabant' variety contained mainly α-thujone (61.0-64.4%), β-thujone (10.4-10.7%) and fenchone (7.7-8.0%), whereas in the cone oil there were α-thujone (42.1%), sabinene (11.2%) and β-thujone (10.2%). The main constituents of the oil from leaves and twigs with leaves of 'Smaragd' variety were α-thujone (49.2-49.3%), beyerene (12.8-13.2%) and sabinene (8.9-9.3%). Conclusions: The yield and chemical composition of the essential oil of T. occidentalis depend on the variety and plant organ. The oil of 'Brabant' variety contained more thujones and less diterpenes in comparison with the oil of 'Smaragd' variety.

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Section: Resultssupporting

confidence: 47%

“…Due to presence of toxic thujone, which can evoke dizziness and convulsions, dose of the oil must be strictly controlled. Pure thujone is used as active ingredient in the production of nasal decongestants of cough suppressants; because of anticancer activity it may be applied in chemotherapies [7].…”

Section: Introductionmentioning

confidence: 99%

Comparison of chemical composition of the essential oils from different parts of Thuja occidentalis L. ‘Brabant’ and T. occidentalis L. ‘Smaragd’

2016

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“…In case of this species, from several other regions the chemical profile with the dominant a-thujone compound was found to be similar: e.g. samples from the United States (Kamdem et al 1993), Poland (Lis et al 2016 and Turkey (Küpeli Akkol et al 2015).…”

Section: Intraspecific Variability Of Thujone Content In Selected Aromentioning

confidence: 74%

“…According to Tan et al (1998), wormwood has been used as traditional medicine in Asia due to its antimalarial, antiviral, antitumor, spasmolytic and other effects. Essential oil of T. occidentalis containing thujone as a major compound, has been widely used in folk medicine for the treatment of hepatoprotection, bronchial catarrh, rheumatism, psoriasis, and uterine carcinomas (Küpeli Akkol et al 2015;Dhiman et al 2012). In homeopathy, the extract of T. occidentalis containing about 65% a-thujone, is used as mother tincture in preparations against a number of diseases (Torres et al 2016).…”

Section: Biological Activities and New Ways For Beneficial Utilizatiomentioning

confidence: 99%

Thujone, a widely debated volatile compound: What do we know about it?

Németh

Nguyen

2020

Phytochem Rev

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Thujone is a volatile monoterpene ketone of plant origin which is produced by several plants that are frequently used for flavoring foods and beverages. The use of thujone and thujone-containing plant parts for human consumption is currently regulated by the European Parliament and Council and the European Medicines Agency. The best known neurotoxic effects are connected to the GABA-gated chloride channel, where a-thujone is a modulator roughly two to three times as potent as the b isomer. Based primarily on in vitro experiments, genotoxicity and carcinogenic properties of thujones have also been detected in parallel with antimutagenic and immune-modulatory effects. Some of the controversial effects seem to be strongly dose-dependent. Data on antidiabetic and antimicrobial activities of thujones may show new ways to use them. This review also describes the main steps of the biosynthetic route of thujones and their occurrence in the plant kingdom. The accumulation of these compounds seems to be more abundant in some plant families (e.g. Asteraceae or Cupressaceae) than in others. Four species (Artemisia absinthium, Salvia

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“…[150] Finally, there may be promise in evaluating the obesity-related hormones of leptin and ghrelin in targeting novel pathways for treatment of PCOS-MBS. [151,152]…”

Section: Novel Therapeutic Targets For Pcos With Mbsmentioning

confidence: 99%

Targets to treat metabolic syndrome in polycystic ovary syndrome

Mahalingaiah

Diamanti-Kandarakis

2015

Expert Opinion on Therapeutic Targets

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Introduction Metabolic syndrome is comprised of a combination of the following states: increased insulin resistance, dyslipidemia, cardiovascular disease, and increased abdominal obesity. Women with polycystic ovary syndrome (PCOS) have an increased risk of developing metabolic syndrome over the course of their lives. Metabolic syndrome increases risk of major cardiovascular events, morbidity, quality of life, and overall health care costs. Though metabolic syndrome in women with PCOS is an area of great concern, there is no effective individual medical therapeutic to adequately treat this issue. Areas Covered This article will review key aspects of metabolic syndrome in PCOS. We will discuss classic and novel therapeutics to address metabolic syndrome in women with PCOS. We will conclude with the importance of developing strategic interventions to increase the compliance to lifestyle and dietary modification, in addition to appreciation of the emerging pharmaceutical therapeutics available. Expert Opinion Innovation in lifestyle modification, including diet, exercise, with and without dedicated stress reduction techniques is the future in treatment of metabolic syndrome in PCOS. Application of novel interventions, such as group medical care, may improve future adherence to lifestyle modification recommendations, in addition to or in combination with pharmaceutical therapeutics.

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Thuja occidentalis L. and its active compound, α-thujone: Promising effects in the treatment of polycystic ovary syndrome without inducing osteoporosis

Cited by 38 publications

References 20 publications

Comparison of chemical composition of the essential oils from different parts of Thuja occidentalis L. ‘Brabant’ and T. occidentalis L. ‘Smaragd’

Comparison of chemical composition of the essential oils from different parts of Thuja occidentalis L. ‘Brabant’ and T. occidentalis L. ‘Smaragd’

Thujone, a widely debated volatile compound: What do we know about it?

Targets to treat metabolic syndrome in polycystic ovary syndrome

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