Thursday, 14 June 2018 2018
DOI: 10.1136/annrheumdis-2018-eular.3146
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THU0614 Interstitial lung disease in patients with antisynthetase syndrome and anti-ro52 antibodies positive

Abstract: BackgroundAntisynthetase syndrome (ASS) is characterised by the presence of myositis, arthritis, interstitial lung disease (ILD), fever, Raynaud’s phenomenon and mechanical’s hand, in the presence of antisynthetase autoantibodies (AA), the most frequent being anti-Jo1, anti-PL7 and anti-PL12. An association between ASS and anti-Ro52 with increased ILD has been described and it is believed that the presence of both antibodies is accompanied by a more severe ILD.ObjectivesTo describe the clinical and analytical … Show more

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“…The remaining 19 studies required one of the following features: myositis, ILD, arthritis, fever, skin rash or mechanic's hands, and RP (12,(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91)(92)(93). Among the remaining definitions, 16 studies defined ASSD as the presence of more than one variable associated with anti-ARS positivity (11,12,(94)(95)(96)(97)(98)(99)(100)(101)(102)(103)(104)(105)(106)(107). In two studies, ASSD was defined as having a connective tissue disease (CTD) diagnosis and simultaneous positive anti-ARS (3,108).…”
Section: Q1: How Has Assd Been Defined In the Published Literature?mentioning
confidence: 99%
See 1 more Smart Citation
“…The remaining 19 studies required one of the following features: myositis, ILD, arthritis, fever, skin rash or mechanic's hands, and RP (12,(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91)(92)(93). Among the remaining definitions, 16 studies defined ASSD as the presence of more than one variable associated with anti-ARS positivity (11,12,(94)(95)(96)(97)(98)(99)(100)(101)(102)(103)(104)(105)(106)(107). In two studies, ASSD was defined as having a connective tissue disease (CTD) diagnosis and simultaneous positive anti-ARS (3,108).…”
Section: Q1: How Has Assd Been Defined In the Published Literature?mentioning
confidence: 99%
“…Frequency of variables used to define anti-synthetase syndrome. ,32,84,85,88,94,95,[97][98][99][100]104) and fever (7 studies)(12,85,88,(94)(95)(96)98). TableIIsummarises the frequencies of use of each variable.…”
mentioning
confidence: 99%