Abstract:BackgroundGenetic variants in uric acid transporters that control serum urate levels have been identified in Europeans by genome-wide association studies [1]. However there is no evidence for association with serum urate (or gout) with the organic anion transporters (OAT) 1–3 (SLC22A6, SLC22A7 and SLC22A8) and multi-drug resistance protein 4 (MRP4) encoded by ABCC4; all four transporters have been implicated in uric acid secretion [2]. The Māori and Pacific (Polynesian) population of New Zealand (NZ) has the h… Show more
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