THU0496 Skeletal deficit due to altered bone quality in type 1 diabetes mellitus

Mohsin, Sahar; Sunny, Jens Jolly; Menon, Kirthi; Kaimala, Suneesh

doi:10.1136/annrheumdis-2018-eular.1957

Cited by 1 publication

(3 citation statements)

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“…Preliminary data from our earlier study showed low levels of serum osteocalcin and bone alkaline phosphatase and increased levels of pentosidine and CTx levels in DM1 38 . It was shown that chronic hyperglycaemic state in type I DM impairs bone remodeling by decreasing bone formation and increasing bone resorption.…”

Section: Discussionmentioning

confidence: 82%

“…The heterogeneous bone microstructure favors the toughening mechanisms in early diabetes through diffuse damage and arrests the propagation of linear microcracks by bridging, splitting and deflecting when it comes across a microstructural feature. Moreover, perhaps due to a decrease in bone anabolic function and altered bone remodeling cycle as reported in DM1 34,38,42 microcracks accumulate and propagate to longer lengths in later stages of DM, compromising bone mechanical properties and eventually fracture. Microdamage should be considered as an important factor in the context of bone quality and fracture risk.…”

Section: Resultsmentioning

confidence: 99%

“…It was shown that chronic hyperglycaemic state in type I DM impairs bone remodeling by decreasing bone formation and increasing bone resorption. An increase in advanced glycation end products also contributes to diabetic osteopathy 38 . The alterations to non-collagenous proteins (NCPs), accumulation of advanced glycation end-products and additionally increase apoptosis of osteocytes may have affected the crack initiation and growth in DM1 31,39–41 .…”

Section: Discussionmentioning

confidence: 99%

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In vivo Labeling of Bone Microdamage in an Animal Model of Type 1 Diabetes Mellitus

Mohsin

Kaimala

AlTamimi

et al. 2019

Sci Rep

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Type 1 diabetes mellitus (DM1) is linked to a decrease in bone strength. Bone strength entails both bone mineral density and bone quality. Limited data are available regarding diabetes-induced microdamage, which can severely influence bone quality. This study has investigated bone microdamage as a measure of bone quality in an animal model of DM1. Microdamage in the neck of the femur was labelled in vivo using multiple fluorochromes at 4, 12 and 24 weeks after the onset of DM1. Microcracks were quantified and their morphology analyzed using microscopy techniques. The mean length of microcracks at 24 weeks, and crack numerical and surface densities were significantly higher (p < 0.05) 4 weeks after the onset of DM1 when compared with control. Diffuse damage density was highest at 12 weeks after the onset of DM1. The arrangement of the collagen fibrils became progressively more irregular from 4 to 24 weeks of DM. This is the first study to analyze microdamage in vivo at different time points of DM1. DM1is associated with microcracks from the early stage, however bone microstructure shows toughening mechanisms that arrest their growth but disease progression further deteriorates bone quality resulting in longer microcracks which may increase fracture risk.

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Section: Discussionmentioning

confidence: 82%