Abstract:Background:Modic type 1 changes (MC1) are vertebral bone marrow lesions associated with non-specific low back pain (LBP). The pathophysiology of MC1 includes inflammation, fibrosis, and high bone turnover. Bone marrow stromal cells (BMSCs) are key regulators of these processes: BMSCs contribute to inflammation by regulating myelopoiesis/osteoclastogenesis; BMSCs can differentiate into osteoblasts contributing to high bone turnover, and BMSCs can differentiate into pro-fibrotic myofibroblasts.Objectives:To iden… Show more
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