2020
DOI: 10.1136/annrheumdis-2020-eular.2833
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Thu0451 cell-Matrix Adhesion of Bone Marrow Stromal Cells in Modic Type 1 Changes Is Increased and Relates to Increased Expression of Integrin Β1

Abstract: Background:Modic type 1 changes (MC1) are vertebral bone marrow lesions associated with non-specific low back pain (LBP). The pathophysiology of MC1 includes inflammation, fibrosis, and high bone turnover. Bone marrow stromal cells (BMSCs) are key regulators of these processes: BMSCs contribute to inflammation by regulating myelopoiesis/osteoclastogenesis; BMSCs can differentiate into osteoblasts contributing to high bone turnover, and BMSCs can differentiate into pro-fibrotic myofibroblasts.Objectives:To iden… Show more

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