THU0385 Utility of the Treatment Thresholds in Frax Proposed by the NOF and the NOGG in Patients with Breast Cancer in Adjuvant Treatment with Aromatase Inhibitors
Abstract:Background
Aromatase Inhibitors (AI) are an important component in adjuvant therapy in postmenopausal women with positive estrogenic receptors in breast cancer. They inhibit the enzyme Cytochrome P450 CYP19, which causes a loss of BMD and consequently an increase in the risk of fracture. In patients with early breast cancer (EBC) in treatment with AI, it is estimated that the risk of fracture is 11% at five years.
FRAX is used to calculate the probability of fracture at 10 years. Within its limitations, it sho… Show more
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