Abstract:Background:Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs, including the skin, joints and kidneys. Though SLE typically cycles through periods of flares and remission, patients often eventually succumb to end-stage kidney or cardiovascular damage1. SLE is characterized by the presence of autoantibodies that form immune complexes resulting in kidney deposition that significantly contribute to lupus nephritis pathogenesis. Phosphatidylinositol 3-kinases (PI3Ks) are divid… Show more
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