Thu0081 mir-17-5p Reduces Inflammation and Bone Erosions in Collagen Induced Arthritis Mice and Directly Targets the Jak-Stat Pathway in Rheumatoid Arthritis Fibroblast-Like Synoviocytes.
Abstract:Background:micro-RNAs (miR) are strong regulators of gene expression. Their involvement in RA key cytokines pathway regulation entitles them as important players in RA pathophysiology. The miR 17-92 cluster has been widely studied in cancer as they regulate cell apoptosis.Objectives:The aims of this study were to screen miR 17-92 cluster’s expression in different RA phenotypes (erosive and non erosive), further elucidate the mechanisms and direct targets involved in miR-17-5p anti-inflammatory role and to inve… Show more
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