THSD7A expression in human cancer

Stahl, Phillip; Hoxha, Elion; Wiech, Thorsten; Schröder, Cornelia; Simon, Ronald; Stahl, Rolf A.K.

doi:10.1002/gcc.22440

Cited by 51 publications

(45 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The second patient had previously been treated for renal cell carcinoma as well as breast carcinoma. Many different types of cancer have been shown to have some degree of positive immunohistochemical staining for THSD7A 6 and a previous case report makes a strong argument for the connection between THSD7A-associated membranous nephropathy and malignancy. 8 In this report, the patient’s tumor was found to be positive for THSD7A on immunohistochemical analysis and have increased copy number of the THSD7A gene.…”

Section: Discussionmentioning

confidence: 92%

“… 5 Recent reports have implicated malignancy as the underlying etiology in some cases of THSD7A-associated membranous nephropathy. 6 , 7 , 8 In an effort to further define the clinicopathologic spectrum of THSD7A-associated membranous nephropathy, we undertook the current retrospective study of 31 patients with follow-up of up to 2 years. We also sought to establish the utility of THSD7A staining in renal biopsies and its correlation with antibody titers for the detection of THSD7A-associated membranous nephropathy.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Tissue staining for THSD7A in glomeruli correlates with serum antibodies in primary membranous nephropathy: a clinicopathological study

Sharma

Larsen

2018

Modern Pathology

View full text Add to dashboard Cite

Thrombospondin type-1 domain-containing 7A (THSD7A) is the most recently recognized target antigen in patients with membranous nephropathy. We stained membranous nephropathy biopsies processed in our laboratory for phospholipase A2 receptor and THSD7A over an 18-month period and selected all THSD7A-positive cases for study. Serum samples from most patients were tested by an indirect immunofluorescence assay for the presence of THSD7A antibodies (Euroimmun). A total of 31 patients were diagnosed with THSD7A-associated membranous nephropathy for a prevalence of 2.4% among patients with membranous nephropathy. The patients were most often male (male-to-female ratio of 1.6) with a mean age of 62 years and a mean proteinuria of 9.6 g per day (range 1.1–15.9). Two of the 31 patients had a history of cancer and none were diagnosed with malignancy on follow-up. Serum samples were available at the time of biopsy from 24 patients and all tested positive for antibodies against THSD7A. Conversely, all 20 serum samples from patients with membranous nephropathy who had negative staining for THSD7A were negative for serum reactivity to THSD7A. We conclude that THSD7A tissue staining of kidney biopsies with membranous nephropathy is a sensitive and specific method for the diagnosis of THSD7A-associated membranous nephropathy and it correlates strongly with the serum antibody testing. We also present the clinicopathologic details of the largest cohort to date of THSD7A-associated membranous nephropathy from a single institution.

show abstract

Section: Discussionmentioning

confidence: 92%

mentioning

confidence: 99%

Tissue staining for THSD7A in glomeruli correlates with serum antibodies in primary membranous nephropathy: a clinicopathological study

Sharma

Larsen

2018

Modern Pathology

View full text Add to dashboard Cite

show abstract

“…In the glomeruli, granular staining for THSD7A along the GCW was observed with negative staining for PLA2R. In the rectal cancer tissue, THSD7A staining was positive, showing a mainly luminal pattern, which was reported as the staining pattern of rectal cancer [12]. THSD7A staining of metastatic lymph nodes revealed deposition in the secondary lymph follicles and in the sinus.…”

Section: Case Presentationmentioning

confidence: 97%

Thrombospondin type-1 domain-containing 7A-associated membranous nephropathy after resection of rectal cancer: a case report

et al. 2019

View full text Add to dashboard Cite

BackgroundThrombospondin type-1 domain-containing 7A (THSD7A) is a target antigen in idiopathic membranous nephropathy (MN). Patients with THSD7A-associated MN are known to have a high possibility of developing malignancy. However, there are few case reports on THSD7A-associated MN with malignancy, and details of its characteristics have not been clarified thoroughly. Here, we report the case of a 77-year-old male patient who was diagnosed with THSD7A-associated MN after resection of rectal cancer.Case presentationA 77-year-old man who had developed bilateral peripheral edema, persistent proteinuria, and nephrotic syndrome was admitted to our hospital. He was diagnosed with MN based on a renal biopsy 3 years after resection of rectal cancer, and positive staining for THSD7A in both kidney and rectal cancer tissues suggested that these two diseases were related. Furthermore, THSD7A staining of metastatic lymph nodes revealed deposition of THSD7A in the secondary lymph follicles and sinus. Recurrence of rectal cancer was suspected; however, tumor recurrence was not observed on chest and abdominal computed tomography (CT) and colonoscopy. There was no lymph node enlargement. The patient was kept on observation with supportive therapy. Consequently, although nephrotic syndrome persisted, obvious recurrence and metastasis of the primary tumor were not observed.ConclusionThis is the first case in which pathological examination results suggested that THSD7A-associated MN was caused by rectal cancer. Based on the reports of THSD7A-associated MN with malignancy and the pathogenesis of MN, lymph node metastasis may be a risk for cancer-related MN.

show abstract

“…A recent study catalogs THSD7A expression by a variety of tumors, and finds strong THSD7A staining in prostate, breast, renal, and colorectal carcinomas. 76 However, overexpression or loss of THSD7A expression was not consistent; in colorectal and renal cell carcinoma, a lack of THSD7A was associated with worse outcome. In contrast, in prostate cancer, overexpression of THSD7A was associated with worse outcomes.…”

Section: Association With Malignancymentioning

confidence: 98%

PLA2R and THSD7A: Disparate Paths to the Same Disease?

Beck

2017

JASN

View full text Add to dashboard Cite

The phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) are the two major autoantigens in primary membranous nephropathy (MN), and define two molecular subclasses of this disease. Both proteins are large transmembrane glycoproteins expressed by the podocyte, and both induce IgG4-predominant humoral immune responses that produce circulating autoantibodies that can be used clinically for diagnostic and monitoring purposes. The biologic roles of these proteins remain speculative, although several features of THSD7A suggest a role in adhesion. PLA2R-associated MN was initially found to associate with risk alleles within , but subsequent studies have shifted the focus to the HLA-DRB locus. Three distinct humoral epitope-containing regions have been defined within the extracellular portion of PLA2R, and it appears that the number of targeted epitopes may determine disease severity. Although similar information is not yet available for THSD7A-associated MN, this form of MN may have a unique association with malignancy. Finally, it appears likely that other autoantigens in primary MN exist. Although protocols similar to those that identified PLA2R and THSD7A may be successful in the identification of novel antigenic targets in MN, newer techniques such as laser-capture mass spectrometry or protein arrays may be helpful as well.

show abstract

THSD7A expression in human cancer

Cited by 51 publications

References 34 publications

Tissue staining for THSD7A in glomeruli correlates with serum antibodies in primary membranous nephropathy: a clinicopathological study

Tissue staining for THSD7A in glomeruli correlates with serum antibodies in primary membranous nephropathy: a clinicopathological study

Thrombospondin type-1 domain-containing 7A-associated membranous nephropathy after resection of rectal cancer: a case report

PLA2R and THSD7A: Disparate Paths to the Same Disease?

Contact Info

Product

Resources

About