Through the MIRRA and what we found there

Abstract

Extract Eosinophil clustering in local tissues often characterises undesirable physiological responses. By the 1990s, the pathogenic nature of specific granule proteins derived from eosinophils had become apparent, solidifying their recognition as the primary producers of inflammatory mediators, including abundant reactive oxygen species and cysteinyl leukotrienes. Since then, it became a common consensus that they are a therapeutic target in allergic diseases.