Thrombus Resolution and Hemodynamic Recovery Using Ultrasound-accelerated Thrombolysis in Acute Pulmonary Embolism

Kennedy, Robert J.; Kenney, Hai H.; Dunfee, Brian L.

doi:10.1016/j.jvir.2013.02.023

Cited by 66 publications

(45 citation statements)

References 25 publications

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“…This dose was associated with a significant decrease in RVD, pulmonary artery pressure, and obstructive index and no significant hemorrhagic complications. Kennedy et al (22) reported the use of a tPA infusion of 1 mg/h/ catheter in 54 of 60 patients with either acute massive or submassive PE. Patients underwent repeat pulmonary angiography and pulmonary artery pressure measurements, and the decision to discontinue treatment was based on improvement of baseline clinical symptoms and interval angiographic evidence of thrombolysis.…”

Section: Discussionmentioning

confidence: 99%

“…The investigators used an average dose of 35.1 mg of tPA over a mean 19.6 hours of infusion time. Their study demonstrated that USAT provides an effective means of resolving clot burden and reversing hemodynamic compromise in patients with acute massive and submassive PE (22). Most recently, the ULTIMA (ULTrasound Accelerated ThrombolysIs of PulMonAry Embolism) trial prospectively randomly assigned 59 patients with intermediate-risk PE to USAT or heparin alone.…”

Section: Discussionmentioning

confidence: 99%

“…Studies involving catheter-directed thrombolysis (CDT) with and without ultrasound have demonstrated a significant comparative improvement with RVD and pulmonary artery pressures without increased risk of major bleeding complication (17)(18)(19)(20)(21)(22). Some authors have suggested that catheter directed therapy be utilized in patients with contraindications to systemic thrombolysis as this population is at intermediate to high risk of death (23,24), however a variety of treatment algorithms were reported.…”

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confidence: 99%

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Ultrasound-Accelerated Catheter-Directed Thrombolysis for Acute Submassive Pulmonary Embolism

Bagla

Smirniotopoulos

Breda

et al. 2015

Journal of Vascular and Interventional Radiology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Ultrasound-Accelerated Catheter-Directed Thrombolysis for Acute Submassive Pulmonary Embolism

Bagla

Smirniotopoulos

Breda

et al. 2015

Journal of Vascular and Interventional Radiology

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“…[5] There are few publications focusing on the utilization of the USAT in high-risk PE patients. Kennedy et al [7] reported 98% complete or near complete clearance of the thrombi among 60 patients with acute PE who were treated with anticoagulation and USAT. The authors reported that it was a safe and effective treatment modality.…”

Section: Discussionmentioning

confidence: 99%

Treatment of pulmonary embolism with ultrasound-accelerated thrombolysis after coronary revascularization

Dönmez¹

2016

Turk Gogus Kalp Dama

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ÖZKalp cerrahisi sonrası pulmoner emboli nadir görülen, fakat ölümcül bir komplikasyondur. Bu yazıda, koroner revaskülarizasyon sonrası yüksek riskli pulmoner emboli gelişen, ultrasonla hızlandırılmış tromboliz ile tedavi edilen 46 yaşında bir erkek olgu sunuldu.Anah tar söz cük ler: Koroner arter baypas; pulmoner emboli; tromboliz. ABSTRACTPulmonary embolism after cardiac surgery is an uncommon, but fatal complication. Herein, we report a 46-year-old male case of high-risk pulmonary embolism after coronary revascularization who was treated with ultrasound-accelerated thrombolysis.

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“…Az ultrahangos percutan mechanikus thrombectomia (EKOS) során ultrahanggal -mint mechanikai rezgés-sel -a feloldandó thrombustömegen repedéseket hoznak létre, elősegítve ezzel a thrombolyticus szer bejutá-sát a thrombusba [8].…”

Section: áBraunclassified

Masszív pulmonalis embolia és thromboemboliás kórképek intervenciós radiológiai kezelése

2015

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A szerzők a vascularis intervenciós radiológiának a vénás rendszer betegségeiben alkalmazott intervenciós radiológiai módszereit mutatják be. A vénás betegségek kezeletlenül vagy nem megfelelő módon kezelve a beteg életét veszé-lyeztetik és krónikus megbetegedések, vénás elégtelenség kialakulásához vezethetnek, ami a betegek számára tartós életminőség-romlást és visszatérő kezelést igénylő klinikai panaszokat okoz. Az intervenciós radiológia számos mód-szerrel rendelkezik, amely időben alkalmazva gyors és teljes gyógyulást eredményezhet. A szerzők ezeket a módsze-reket foglalják össze, remélve, hogy az intervenciós radiológiai centrumok létrehozásával a módszerek széles tömegek számára hozzáférhetővé válnak és beilleszkednek a napi rutin-betegellátásba. A vénás betegségek gyakorisága és az életminőséget jelentősen befolyásoló hatása miatt a szerzők szeretnék az érdeklődést felkelteni az intervenciós radiológiai módszerek iránt és a fi gyelmet ráirányítani a modern terápiás lehetőségekre. Orv. Hetil., 2015, 156(17), 674-679.Kulcsszavak: mélyvénás thrombosis, thrombolysis, szelektív thrombolysis, vénás stentelés, pulmonalis embolia, mechanikus thrombusdarabolás Interventional radiological treatment of extensive pulmonary embolism and thromboembolic diseasesThe authors discuss interventional radiological methods in the fi eld of vascular interventions applied in venous system diseases. Venous diseases can be lifethreatening without appropriate treatment and can lead to chronic venous diseases and venous insuffi ciency which result in long lasting life quality destruction. In addition, recurrent clinical symptoms are require additional treatments. Interventional radiology has several methods that can provide fast and complete recovery if applied in time. The authors summarize these methods hoping that they will be available for a wide range of patients through the establishment of Interventional Radiological Centres and will be a part of the daily routine of patient care. Regarding the frequency of venous diseases and its infl uance on life quality the authors would like to draw attention to interventional radiological techniques and modern therapeutic possibilities.Keywords: deep vein thrombosis, thrombolysis, selective thrombolysis, venous stenting, pulmonary embolism, mechanical thrombus fragmentation Battyáni, I., Dósa, E., Harmat Z. [Interventional radiological treatment of extensive pulmonary embolism and thromboembolic diseases]. Orv. Hetil., 2015, 156(17), 674-679. (Beérkezett: 2015 elfogadva: 2015. február 21.) Rövidítések CTPA = komputertomográfi ás pulmonalis angiográfi a; EKOS = ultrahangos percutan mechanikus thrombectomia; IU = nemzetközi egység; MRI = mágneses rezonanciás vizsgá-lat; PE = pulmonalis embolia; PTD = percutan thrombectomiás eszköz; PTX = pneumothorax; r-tPA = rekombináns szöveti plazminogén aktivátor; sc. = subcutan; SK = sztreptokináz; SP54 = sodium pentosanpolysulfate; TIPS = transjugularis intrahepaticus portoszisztémás sönt; UK = urokináz

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Thrombus Resolution and Hemodynamic Recovery Using Ultrasound-accelerated Thrombolysis in Acute Pulmonary Embolism

Cited by 66 publications

References 25 publications

Ultrasound-Accelerated Catheter-Directed Thrombolysis for Acute Submassive Pulmonary Embolism

Ultrasound-Accelerated Catheter-Directed Thrombolysis for Acute Submassive Pulmonary Embolism

Treatment of pulmonary embolism with ultrasound-accelerated thrombolysis after coronary revascularization

Masszív pulmonalis embolia és thromboemboliás kórképek intervenciós radiológiai kezelése

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