Thrombus organization and healing in an experimental aneurysm model. Part II. The effect of various types of bioactive bioabsorbable polymeric coils

Yuki, Ichiro; Lee, Daniel; Murayama, Yuichi; Chiang, Alexander; Vinters, Harry V.; Nishimura, Ichiro; Wang, Chiachien J.; Ishii, Akira; Wu, Benjamin M.; Viñuela, Fernando

doi:10.3171/jns-07/07/0109

Cited by 27 publications

(15 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Raymond, et al reported that nearly 50% of subsequent recurrences were present by 6 months after coiling in humans 9 . Various mechanisms underlying late aneurysm recanalization have been proposed, including 1) growth of aneurysm itself 10, 11 , 2) poor thrombus organization as a result of of the biologically inert platinum coil construction 12 , 3) instability of fresh, unorganized thrombus and degradation by fibrolysis, 4) continued transmission of blood pulsation affecting the association of coil-thrombus complex 13 , 5) lack of neointima formation across the neck of aneurysm 14 , and 6) formation of neovessels inside the aneurysms lumen exposing the aneurysm cavity to blood flow.…”

Section: Mechanism Of Recurrencementioning

confidence: 99%

Mechanisms of Healing in Coiled Intracranial Aneurysms: A Review of the Literature

Brinjikji

Kallmes

Kadirvel

2014

American Journal of Neuroradiology

View full text Add to dashboard Cite

Summary Recanalization of intracranial aneurysms following endovascular coiling remains a frustratingly common occurrence. An understanding of the molecular and histopathological mechanisms of aneurysm healing following coil embolization is essential to improving aneurysm occlusion rates. Histolopathologic studies in coiled human and experimental aneurysms suggest that during the first month post-coiling, thrombus formation and active inflammation occur within the aneurysm dome. Several months following embolization, the aneurysm is excluded from the parent vessel by formation of a neointimal layer, which is often thin and discontinuous, across the aneurysm neck. Numerous coil modifications and systemic therapies have been tested in animals and humans in an attempt to improve the aneurysm healing process; these modifications have met with variable levels of success. In this review, we summarize the histopathologic and molecular biology of aneurysm healing and discuss how these findings have been applied in an attempt to improve angiographic outcomes in patients harboring intracranial aneurysm.

show abstract

Section: Mechanism Of Recurrencementioning

confidence: 99%

Mechanisms of Healing in Coiled Intracranial Aneurysms: A Review of the Literature

Brinjikji

Kallmes

Kadirvel

2014

American Journal of Neuroradiology

View full text Add to dashboard Cite

show abstract

“…Thus, the number of available stains is limited and the quality of the staining is inferior to that of paraffin embedded samples. In the present report, the tissue samples were processed using previously described paraffin embedding techniques 1 2. The coils were manually removed under guidance by a stereoscopic microscope and prepared using a variety of stains for multiple immunohistochemical analyses.…”

Section: Discussionmentioning

confidence: 99%

“…Each 1 mm paraffin section was then re-embedded in the paraffin and 10 μm sections were finally made using a microtome. Technical details were as previously described 1 2. Various staining techniques such as H&E, Masson Trichrome, α smooth muscle actin (αSMA), and factor VIII were performed.…”

Section: Outcome and Follow-upmentioning

confidence: 99%

Immunohistochemical analysis of a ruptured basilar top aneurysm autopsied 22 years after embolization with Guglielmi detachable coils

et al. 2014

View full text Add to dashboard Cite

The authors report on the histologic and immunohistochemical analyses of a cerebral aneurysm embolized with platinum coils and with the longest observation period. A 58-year-old woman presenting with subarachnoid hemorrhage due to ruptured basilar top aneurysm was treated with Guglielmi detachable coils (GDC) 22 years ago. She was the 15th case since the GDC was introduced. After she died of unrelated causes, an autopsy and thorough histologic examination were performed. Gross examination revealed no adhesion between the aneurysm wall and the surrounding brain tissue. Histologic and immunohistochemical analyses demonstrated that the cavity of the aneurysm was filled with homogeneous collagenous fibrous tissue, while the neck was completely covered by a dense collagenous neointima and a smooth muscle cell layer. The unique histologic results of this case may contribute to a better understanding of the long-term evolution of the healing process in intracranial aneurysms successfully treated with the GDC.

show abstract

“…Second are the models mainly used to determine the technical proficiency of endovascular devices or to assess histopathological changes after endovascular treatment; however, this class is not used to determine the underlying mechanisms of CA formation. These models are surgically induced by creating a venous pouch mainly in the carotid artery of dogs or pigs [42–45]. …”

Section: Overview Of Animal Models Of Camentioning

confidence: 99%

The Development and the Use of Experimental Animal Models to Study the Underlying Mechanisms of CA Formation

Aoki

Nakagawa

2010

BioMed Research International

View full text Add to dashboard Cite

Cerebral aneurysms (CAs) have a high prevalence and can cause a lethal subarachnoid hemorrhage. Currently, CAs can only be treated with invasive surgical procedures. To unravel the underlying mechanisms of CA formation and to develop new therapeutic drugs for CAs, animal models of CA have been established, modified, and analyzed. Experimental findings from these models have clarified some of the potential mechanisms of CA formation, especially the relationship between hemodynamic stress and chronic inflammation. Increased hemodynamic stress acting at the site of bifurcation of cerebral arteries triggers an inflammatory response mediated by various proinflammatory molecules in arterial walls, inducing pathological changes in the models similar to those observed in the walls of human CAs. Findings from animal studies have provided new insights into CA formation and may contribute to the development of new therapeutic drugs for CAs.

show abstract

Thrombus organization and healing in an experimental aneurysm model. Part II. The effect of various types of bioactive bioabsorbable polymeric coils

Cited by 27 publications

References 34 publications

Mechanisms of Healing in Coiled Intracranial Aneurysms: A Review of the Literature

Mechanisms of Healing in Coiled Intracranial Aneurysms: A Review of the Literature

Immunohistochemical analysis of a ruptured basilar top aneurysm autopsied 22 years after embolization with Guglielmi detachable coils

The Development and the Use of Experimental Animal Models to Study the Underlying Mechanisms of CA Formation

Contact Info

Product

Resources

About