Thrombus formation on transcatheter ASD occluder device in a patient with coagulation factor XII deficiency

Incidence and clinical course of thrombus formation on atrial septal defect and patient foramen ovale closure devices in 1,000 consecutive patients

“…Atrial thrombi after transcatheter ASD and PFO closure are rare complications (20,24,25). We investigated the incidence of thrombus formation on nine different devices in 1,000 consecutive patients to determine possible predictors.…”

“…Coagulation disorders such as protein C deficiency, protein S deficiency, and activated protein C resistance did not exist in our thrombus cases; only a hyperactivity of factor VIII and a thrombocytosis could be found in two patients. Gastmann et al (24) reported a case of a left-sided thrombus formation on an ASDOS device resulting in cerebral thromboembolism. This patient had a deficiency of coagulation factor XII.…”

Clinical, echocardiographic and histopathologic findings in nine patients with surgically explanted ASD/PFO devices: Do we know enough about the healing process in humans?

“…Early thrombi were interpreted as a result of missing endothelialization and some groups therefore started antiplatelet therapy the day before the implantation [9]. The incidence of thrombus formation (1.2 to 17.5%) also seems to be highly related to the design and type of the device [8,9,20,21]. Whereas in the largest follow-up series dealing with that problem [8], the Amplatzer ASD/PFO occluder was the only type of device with no thrombus formation in the early follow-up, supported also by data from smaller series [22].…”

Comparative incidence of thrombosis in reported cases of deficiencies of factors of the contact phase of blood coagulation

“…After that publication, a few reports dealt with arterial or venous thrombotic events, occurring in other patients with factor XII deficiency [7][8][9][10][11][12][13][14][15]. Furthermore old papers which had reported thrombotic events in some of these patients but had received little attention were re-evaluated in their importance [16][17][18][19][20][21][22][23][24][25]. A few cases have been reported even in recent years [26][27][28][29][30][31][32].…”