Thrombus Formation on Atherosclerotic Plaques: Pathogenesis and Clinical Consequences

Abstract

Long-term treatment with potent antithrombotic drugs, such as tissue factor or factor Xa inhibitors, that effectively block thrombosis without causing bleeding complications could help reduce death from cardiovascular disease.

Positive affect and health-related neuroendocrine, cardiovascular, and inflammatory processes

“…Plasma fibrinogen is an inflammatory marker and predictor of future coronary heart disease, heightening risk through increasing blood viscosity, infiltration of the arterial wall, stimulation of atherogenic cell proliferation, and platelet aggregation (40,41). Although the fibrinogen stress responses were small in absolute terms, the relative increase was Ͼ12 times greater in the lowest compared with highest happiness group.…”

Potential for the Use of the Solitaire Stent for Recanalization of Middle Cerebral Artery Occlusion without a Susceptibility Vessel Sign

“…This phenomenon, known as "atherothrombosis," is due to the advanced lipid core of the atherosclerotic plaque, which is rich in tissue factors that activate platelets and promote coagulation if released into the blood by either rupture or ulceration of the plaque. 30 Thus, vulnerable plaques with intra-arterial thrombus may act as the cause of acute ischemic stroke with in situ stenosis rather than hemodynamic instability. 26,28 Because the MCA SVS reflects clot composition and burden, the atherothrombus may exist without demonstrating the MCA SVS on GRE MR imaging because of a different clot composition or a small amount of clotting.…”

Expression Profiling Identifies Genes That Continue to Respond to Insulin in Adipocytes Made Insulin-resistant by Treatment with Tumor Necrosis Factor-α

“…However, despite these in vitro results, few target genes have been identified for EGR-1 in vivo. One such gene is tissue factor (32), a regulatory component of the coagulation system and a cardiovascular risk gene (50). Although there is no published link between EGR-1 and gene expression in adipocytes, several of the reported downstream target genes for EGR-1 are also expressed by the adipocytes.…”