Thrombus Formation on a Left Atrial Appendage Closure Device

Cardona, Lorette; Galrinho, Ana; Branco, Luísa Moura; Leal, Ana; Fiarresga, António; Sousa, Lídia; Cruz, Ferreira Rui

doi:10.1161/circulationaha.110.004135

Cited by 16 publications

(8 citation statements)

References 9 publications

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“…Data from the Asia Pacific experience and Canadian experience have demonstrated a similar high rate of implant success and similar rate of procedural complications [35,36]. Thrombus formation on the device has been reported [37][38][39]. The ACP device has CE mark approval but is not approved in the United States at this time.…”

Section: Watchmanmentioning

confidence: 85%

Left atrial appendage closure - Where are we now?

Sánchez¹,

Holmes²

2016

jshd

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Atrial fibrillation is the most common arrhythmia with significant morbidity and mortality. The most feared complication of atrial fibrillation remains stroke. While anticoagulation remains the cornerstone of stroke prevention in patients with atrial fibrillation, patients continue to be under treated due to misinformation, intolerance, as well as relative and absolute contraindications. The left atrial appendage has been implicated in thrombus formation in patients with atrial fibrillation. Left atrial appendage closure has been devised as an alternative strategy for decreasing stroke risk in patients with atrial fibrillation. Percutaneous left atrial appendage closure is currently being developed as a possible alternative to anticoagulation in patients at high risk for stroke especially among patients with relative or absolute contraindications to long-term anticoagulation. The PROTECT AF trials provides the first randomized, controlled trial data demonstrating proof of concept of left atrial appendage closure with the WATCHMAN device. Further data are explored in this review. Limited data are available with other devices. However, several devices are promising entries into the realm of left atrial appendage closure offering options to an under treated patient population.

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Section: Watchmanmentioning

confidence: 85%

Left atrial appendage closure - Where are we now?

Sánchez¹,

Holmes²

2016

jshd

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“…Three rows of anchors along the maximum circumference secure the cage within the LAA ostium. Although it produced positive five-year study results, the device was discontinued in 20078 for commercial reasons 29,33. The PLAATO device diameters ranged from 15–32 mm and were selected such that they were 20–40% larger than the LAA ostium diameter (Fig.…”

Section: Left Atrial Closure Devicesmentioning

confidence: 99%

Left Atrial Appendage Closure Devices

Romero

Perez

Krumerman

et al. 2014

Clin Med Insights Cardiol

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Atrial fibrillation (AF) increases the risk for thromboembolic stroke five-fold. The left atrial appendage (LAA) has been shown to be the main source of thrombus formation in the majority of strokes associated with AF. Oral anticoagulation with warfarin and novel anticoagulants remains the standard of care; however, it has several limitations, including bleeding and poor compliance. Occlusion of the LAA has been shown to be an alternative therapeutic approach to drug therapy. The purpose of this article is to review the different techniques and devices that have emerged for the purpose of occluding this structure, with a particular emphasis on the efficacy and safety studies published to date in the medical literature.

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“…In der bislang größten Serie mit echokardiographischem Langzeit-Follow-up bei 20 Patienten wurden unter alleiniger dualer Plättchenhem-mung keine Thromben berichtet [13]. Jedoch gibt es 2 publizierte Fallberichte mit thrombotischen Auflagerungen auf dem ACP-Okkluder [14,15]. In unserer Arbeitsgruppe zeigte sich bei den ersten 34 Patienten nach ACP-Implantation eine Häufung von Fällen mit Thrombenbildung auf dem Okkluder: 6 Patienten (17%) entwickelten thrombotische Auflagerungen auf der ACP-Scheibe (.…”

Section: Introductionunclassified

Interventioneller Vorhofohrverschluss

Plicht

Erbel

Konorza

2012

Herz

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As a potential alternative to long-term oral anticoagulation with vitamin K antagonists in patients with atrial fibrillation, the interventional left atrial appendage occlusion has shown to be non-inferior regarding neurological events. With the new oral direct factor II and factor Xa inhibitors playing an emerging role in stroke prophylaxis, an individual treatment strategy has to be found weighing bleeding and stroke risk against the peri-interventional complication rate based on established risk scores.

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Thrombus Formation on a Left Atrial Appendage Closure Device

Cited by 16 publications

References 9 publications

Left atrial appendage closure - Where are we now?

Left atrial appendage closure - Where are we now?

Left Atrial Appendage Closure Devices

Interventioneller Vorhofohrverschluss

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