Thrombotic thrombocytopenic purpura presenting as recurrent thrombocytopenia in a young female — A case report

Shanmugam, Sri Gayathri; Nagarajan, Priyathersini; Muralikrishnan, Srikanth; Balasubramanian, Archana B.

doi:10.1016/j.htct.2019.10.005

Cited by 1 publication

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“…Microvascular occlusion results in organ damage, most notably of the kidney and brain [ 4 ]. The combination of microangiopathic hemolytic anemia and thrombocytopenia without other explanation is sufficient to diagnose and treat TTP as a hematological emergency, due to its fatal feature if untreated [ 4 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

COVID-19-Induced Fatal Thrombotic Thrombocytopenic Purpura in a Healthy Young Patient

Pereira

Ruschel

Schneider

et al. 2022

Case Reports in Critical Care

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Since the global coronavirus disease 2019 (COVID-19) pandemic began, findings indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might induce autoimmune disorders. Thrombotic thrombocytopenic purpura (TTP) is a devastating disease if not emergently treated. It presents with severe thrombocytopenia, microangiopathic hemolytic anemia, and neurologic findings with or without renal insufficiency. The antibody-mediated reduced activity of the disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) induces the accumulation of ultrahigh-molecular-weight multimers of von Willebrand factor, leading to platelet aggregation and thrombosis. TTP can be an unusual presentation of COVID-19 disease mediated by the virus-induced immune response. We report a case of a healthy young patient presenting with the classic TTP pentad a few days after a diagnosis of COVID-19 confirmed by a positive SARS-CoV-2 RT-PCR test. The patient was initially treated with high-dose methylprednisolone and fresh frozen plasma until she was transferred to a tertiary care facility and plasma exchange was available. She evolved with a malignant ischemic vascular accident and was declared brain-dead 24 hours after the first plasma exchange section.

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Section: Introductionmentioning

confidence: 99%