Thrombotic thrombocytopenic purpura following hemorrhagic colitis due to Escherichia coli 0157:H7

Kovacs, Michael J.; Roddy, Janet; Grégoire, Sylvie; Cameron, D. William; Eidus, L; Drouin, Jeanne

doi:10.1016/0002-9343(90)90470-x

Cited by 42 publications

(17 citation statements)

References 16 publications

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“…These are drugs, autoimmune disease, malignancy and infection, particularly Escherichia coli 0157:H7 and human immunodeficiency virus (HIV). Although E. coli 0157:H7 is more closely linked with HUS, there have been cases with typical TTP features (Morrison et al , 1986; Kovacs et al , 1990). Of note VWF‐CP deficiency was detected in one of 29 children with epidemic HUS, 25 of whom were positive for verotoxin (Hunt et al, 2001).…”

Section: Laboratory Features and Investigationmentioning

confidence: 99%

Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias

et al. 2003

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Section: Laboratory Features and Investigationmentioning

confidence: 99%

Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias

et al. 2003

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“…Hemolyticuremic syndrome (HUS) is a closely related condition with predominantly renal manifestations and is characterized by a constellation of symptoms, including microangiopathic hemolytic anemia, thrombocytopenia, fever, and renal failure [1,3]. Idiopathic TTP primarily occurs in adults, whereas HUS also develops in ∼15% of children infected with Escherichia coli strain O157: H7 [4,5]. TTP and adult HUS are considered part of a spectrum of diseases collectively known as "thrombotic microangiopathies" (TMA) because they have ognized in 1984 [27] and since then, both TTP and HUS have been reported in HIV-infected patients [28][29][30][31].…”

mentioning

confidence: 99%

HIV‐Associated Thrombotic Microangiopathy in the Era of Highly Active Antiretroviral Therapy: An Observational Study

Becker

Fusco

et al. 2004

CLIN INFECT DIS

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The prevalence and predisposing factors of thrombotic microangiopathy (TMA) in the era of highly active antiretroviral therapy (HAART) were evaluated among patients in the Collaborations in Human Immunodeficiency Virus (HIV) Outcomes Research/US cohort. Of 6022 patients, 17 (0.3%) had TMA, with unadjusted incidences per 100 person-years of 0.079 for TMA, 0.009 for thrombotic thrombocytopenic purpura, and 0.069 for hemolytic-uremic syndrome. Compared with patients without TMA, patients with TMA had lower mean CD4(+) cell counts (197 vs. 439 cells/mm(3); P=.0009) and higher mean log(10) HIV-1 RNA levels (4.6 vs. 3.3 copies/mL; P=.0001) at last follow-up and a significantly greater incidence of acquired immune deficiency syndrome (82.4% vs. 55.3%; P=.025), Mycobacterium avium complex infection (17.6% vs. 3.3%; P=.018), hepatitis C (29.4% vs. 11.3%; P=.001), and death (41.2% vs. 7.4%; P<.0001). The prevalence of herpes and use of antiherpetics were slightly higher for patients with TMA, but unadjusted distributions were not statistically significant. TMA in a cohort surveyed after the introduction of HAART was rare and was associated with advanced HIV disease.

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“…The disease has been associated with bacterial, viral, or rickettsial infection [11][12][13], systemic lupus erythematosus [14], other connective tissue disorders [15], and solid tumors [16]. Some other reports suggest a relation between TTP and drugs including ticlopidine [17], penicillin [18], penicillamine [19], contraceptive treatment [20] and heparin [21].…”

Section: Resultsmentioning

confidence: 99%

Central Nervous System Involvement in Thrombotic Thrombocytopenic Purpura

Druschky¹,

Erbguth²,

Strauss

et al. 1998

Eur Neurol

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Thrombotic thrombocytopenic purpura (TTP) is an uncommon multisystem disease characterized by microangiopathic hemolytic anemia, thrombocytopenic purpura, fluctuating neurologic dysfunctions, renal disease, and fever. Delayed diagnosis and treatment may lead to a high mortality rate that can be as great as 90%. We describe 7 patients in whom CNS involvement was the first clinical manifestation of TTP. Despite early diagnosis and treatment, 3 patients died because of multiple system organ failure. Four patients recovered completely. In patients with focal neurologic disorders in whom infectious CNS diseases were excluded TTP should be considered in the differential diagnosis.

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Thrombotic thrombocytopenic purpura following hemorrhagic colitis due to Escherichia coli 0157:H7

Cited by 42 publications

References 16 publications

Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias

Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias

HIV‐Associated Thrombotic Microangiopathy in the Era of Highly Active Antiretroviral Therapy: An Observational Study

Central Nervous System Involvement in Thrombotic Thrombocytopenic Purpura

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