Thrombotic Inception at Nano-Scale

Deb, Suryyani; Dasgupta, Anjan Kumar

doi:10.5772/29572

Cited by 3 publications

(2 citation statements)

References 82 publications

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“…Metallic NP-induced platelet aggregation is inhibited when ADP pathway is blocked by an appropriate concentration of clopidogrel or apyrase inhibiting therefore the secondary wave of platelet aggregation which depends mainly on granule release. GPIIbIIIa seems to play also an important role in metallic NP-induced platelet aggregation as in the presence of Arg-Gly-Asp-Ser (RGDS), a tetra-peptide which binds and inhibits activated but not resting GpIIbIIIa, platelet aggregation is attenuated (86).…”

Section: Metallic Nanoparticles-platelets Interactionsmentioning

confidence: 99%

Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications

Hante

Medina

Santos-Martínez

2019

Front. Cardiovasc. Med.

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Nanomaterials have been recently introduced as potential diagnostic and therapeutic tools in the medical field. One of the main concerns in relation to the use of nanomaterials in humans is their potential toxicity profile and blood compatibility. In fact, and due to their small size, NPs can translocate into the systemic circulation even after dermal contact, inhalation, or oral ingestion. Once in the blood stream, nanoparticles become in contact with the different components of the blood and can potentially interfere with normal platelet function leading to bleeding or thrombosis. Metallic NPs have been already used for diagnosis and treatment purposes due to their unique characteristics. However, the potential interactions between metallic NPs and platelets has not been widely studied and reported. This review focuses on the factors that can affect platelet activation and aggregation by metal NPs and the nature of such interactions, providing a summary of the effect of various metal NPs on platelet function available in the literature.

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Section: Metallic Nanoparticles-platelets Interactionsmentioning

confidence: 99%

Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications

Hante

Medina

Santos-Martínez

2019

Front. Cardiovasc. Med.

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“…(i) Thrombus imaging: Acute coronary syndrome (ACS) is one of the leading causes of death in the world 58 59 60 61 62 . Atherosclerotic plaques in humans consist of different bio-components which are heterogeneous in nature, i.e.…”

Section: Nanotechnology and Cardiovascular Diseasesmentioning

confidence: 99%

Nanoimaging in cardiovascular diseases: Current state of the art

Deb¹,

Ghosh²,

Shetty³

2015

Indian J Med Res

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Nanotechnology has been integrated into healthcare system in terms of diagnosis as well as therapy. The massive impact of imaging nanotechnology has a deeper intervention in cardiology i.e. as contrast agents, to target vulnerable plaques with site specificity and in a theranostic approach to treat these plaques, stem cell delivery in necrotic myocardium, etc. Thus cardiovascular nanoimaging is not limited to simple diagnosis but also can help real time tracking during therapy as well as surgery. The present review provides a comprehensive description of the molecular imaging techniques for cardiovascular diseases with the help of nanotechnology and the potential clinical implications of nanotechnology for future applications.

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Cardiovascular Nanomedicine

Deb¹

2015

Advanced Theranostic Materials

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Thrombotic Inception at Nano-Scale

Cited by 3 publications

References 82 publications

Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications

Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications

Nanoimaging in cardiovascular diseases: Current state of the art

Cardiovascular Nanomedicine

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