Thrombotic complications in patients with congenital heart defects after cardiac surgery

Abstract

The thrombotic complications develop in 3,6–13% of children with congenital heart defects in the postoperative period, which makes the diagnosis and prevention of thrombosis relevant. Permanent risk factors include the carriage of mutations/polymorphic variants of genes, leading to an imbalance in the procoagulant and anticoagulant hemostatic systems. In some cases, children after cardiac surgery are prescribed anticoagulants, warfarin is the most commonly used vitamin K antagonist, which can cause warfarin-associated skin necrosis as a result of vascular microthrombosis of the microvasculature. We provide our own observation – a case of thrombosis and warfarin-associated skin necrosis in a child after a multi-stage correction of congenital heart defect on the background of indirect anticoagulant therapy.