Thrombotic complications in patients with cancer: Advances in pathogenesis, prevention, and treatment—A report from ICTHIC 2021

Falanga, Anna; Brenner, Benjamin; Khorana, Alok A.; Francis, Charles W.

doi:10.1002/rth2.12744

Cited by 11 publications

(11 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Los indicadores biológicos, como los niveles de inhibidor del activador del plasminógeno-1 (PAI-1) y el activador tisular del plasminógeno (TPA), también han sido relacionados con un incremento en la probabilidad de desarrollar cáncer colorrectal, cáncer de mama y otros factores asociados con la formación de coágulos sanguíneos. Además, se han desarrollado modelos de evaluación de riesgo para estratificar a los pacientes que se beneficiarían de la tromboprofilaxis (Falanga et al, 2022;Costa & Araujo, 2021).…”

Section: Diagnóstico Exámenes De Laboratoriounclassified

Tromboembolismo en pacientes oncológicos.

Morales-Luzuriaga,

Morales-Solis

2023

MQRInvestigar

View full text Add to dashboard Cite

Introducción: Los individuos que presentan cáncer en fase activa se encuentran en una situación de riesgo de desarrollar tromboembolismo venoso, lo cual puede acarrear importantes consecuencias en términos de deterioro de la salud, mayor riesgo de muerte y un considerable impacto económico en el sistema de atención médica. La profilaxis reduce el riesgo de tromboembolismo venoso, pero no es factible para todos los pacientes con cáncer ambulatorios debido al mayor riesgo de hemorragia. Objetivo: Describir los mecanismos fisiopatológicos, manifestaciones clínicas, métodos diagnósticos, escalas de riesgo y el manejo del tromboembolismo en pacientes con cáncer. Metodología: se llevó a cabo una exhaustiva revisión de la literatura médica indexada, para lo cual se tomaron en cuenta 36 artículos que cumplían con los criterios de admisibilidad y exclusión. Se utilizó los descriptores del área de salud y plataformas medicas con investigaciones de alto impacto. Conclusión: La puntuación de Khorana, que indica el riesgo de tromboembolismo venoso en pacientes con cáncer, ha sido validada como una herramienta para seleccionar aquellos que pueden beneficiarse de la tromboprofilaxis con heparinas de bajo peso molecular durante 3 a 6 meses.

show abstract

Section: Diagnóstico Exámenes De Laboratoriounclassified

Tromboembolismo en pacientes oncológicos.

Morales-Luzuriaga,

Morales-Solis

2023

MQRInvestigar

View full text Add to dashboard Cite

show abstract

“…All the mechanisms described above, together with other general factors, such as the compression stasis of the tumour mass, infections, and bed rest, may contribute to the hypercoagulable state of OSCC patients. However, a paradoxical situation has been described for OSCC patients because, unlike other types of cancer, they seem to present a low incidence of thrombosis [ 1 , 2 , 3 ].…”

Section: Oscc and Thrombosis: A Paradoxical Relationship?mentioning

confidence: 99%

“…Several biological mechanisms on a hypercoagulable state induced by malignant cells have been described, bringing together different neoplasms in different sites [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Oral Squamous Cell Carcinoma-Associated Thrombosis: What Evidence?

Gennaro

Cristofaro

Ferretti

et al. 2022

Cancers

View full text Add to dashboard Cite

Venous thromboembolism (VTE) disease is the second leading cause of mortality in cancer patients. In the general population, the annual incidence of a thromboembolic event is about 117 cases per 100,000 persons, but cancer increases this risk about fourfold, while in patients receiving chemotherapy and surgical treatment, it is about sevenfold. Oral squamous cell carcinoma (OSCC) is the most common form of oral cancer and represents a multistep process in which environmental factors and genetic alterations are implicated. Thrombotic risk is considered empirically low in OSCC patients, although few data are available. Having limited information available may result in poor awareness of VTE prevention in OSCC, risking jeopardising the oncologic treatment and increasing the morbidity and mortality among these patients. In this paper, the topic of OSCC-associated thrombosis will be discussed.

show abstract

“…Deep venous thrombosis (DVT) is an impaired venous reflux disorder caused by abnormal clotting of blood in the deep veins that has a significant negative impact on a patient's safety and quality of life. 1 – 3 Hence, it is of particular importance to evaluate the risk factors of DVT before thrombosis and take effective clinical measures to prevent, find, and treat DVT in time.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Risk Factors of Postoperative Lower Extremity Deep Venous Thrombosis in Patients With Cervical Cancer

Cheng,

Gao,

et al. 2024

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

Deep venous thrombosis (DVT) has a significant negative impact on surgical and tumor patient's safety and quality of life. There was no specific report on the incidence and risk factors of postoperative lower extremity DVT in cervical cancer patients. Analysis of the risk factors of postoperative DVT in patients with cervical cancer is of great clinical significance for prevention and treatment. We retrospectively analyzed 309 cervical cancer patients treated by the Hubei Cervical Cancer Prevention Center and used a logistic regression model to test the risk variables of postoperative lower extremity deep venous thrombosis in cervical cancer patients. By univariate analyses, the results of the study showed that the incidence of postoperative DVT was significantly increased in cervical cancer patients complicated with old age, obesity, high preoperative plasma D-dimer level, increased preoperative triglyceride level, chronic diseases (hypertension, diabetes, and cardiovascular disease), open surgery, long operation time, intraoperative blood transfusion, advanced tumor stage, and preoperative chemotherapy/radiotherapy. Advanced age, obesity, elevated preoperative D-dimer level, high preoperative triglyceride level, and open surgery were independent risk factors for postoperative lower extremity DVT in patients with cervical cancer by multivariate regression analyses (all P < .05). In gynecologic patients with cervical cancer, there is a high incidence of postoperative lower extremity DVT. Clinicians should develop systematic and comprehensive prevention and treatment measures for the risk factors to lower this morbidity and improve patient prognosis.

show abstract

Thrombotic complications in patients with cancer: Advances in pathogenesis, prevention, and treatment—A report from ICTHIC 2021

Cited by 11 publications

References 104 publications

Tromboembolismo en pacientes oncológicos.

Tromboembolismo en pacientes oncológicos.

Oral Squamous Cell Carcinoma-Associated Thrombosis: What Evidence?

Analysis of Risk Factors of Postoperative Lower Extremity Deep Venous Thrombosis in Patients With Cervical Cancer

Contact Info

Product

Resources

About