Thrombotic and Hypercoagulability Complications of COVID-19: An Update

Shibeeb, Sapha; Ahmad, Muneera Naseer

doi:10.2147/jbm.s316014

Cited by 16 publications

(9 citation statements)

References 64 publications

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“…Although there is a correlation between COVID-19 and hypercoagulability, not much is known about the mechanism [ 5 ]. One possible mechanism being flouted is an increased inflammatory response, which has resulted in hypercoagulable states [ 2 ]. It is thought that the damage to the endothelial lining leads to a wave of events, including, but not limited to, activation of the coagulation cascade and release of pro-inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…One process that has been extensively seen and documented is that of hypercoagulable states and coagulopathies. Of note, these hypercoagulable states have been linked to a worse prognosis especially when seen in critically ill patients [ 2 ]. This case report describes a COVID-19 patient who developed arterial microvascular thromboembolism.…”

Section: Introductionmentioning

confidence: 99%

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COVID-19-Induced Hypercoagulability: A Case Report

Sperry¹,

Joseph²,

Yglesias³

2022

Cureus

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We report a case of atherothrombotic microembolism in a 53-year-old male diagnosed with coronavirus disease 2019 (COVID-19) prior to hospital admission. Upon admission, Day 9 after diagnosis, he presented with COVID-19 pneumonia and mottling of the lower extremities. The patient was treated with anticoagulation therapy. The lower extremity angiogram showed a patent posterior tibial artery and a patent peroneal artery. Despite initial anticoagulation therapy, toe and transmetatarsal amputations were required. However, a below-the-knee amputation was subsequently required due to continued worsening and extension of mottling. Unfortunately, the patient ultimately expired from cardiopulmonary arrest before any other surgical intervention could be done.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

COVID-19-Induced Hypercoagulability: A Case Report

Sperry¹,

Joseph²,

Yglesias³

2022

Cureus

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“…Recent theories on COVID-19 pathophysiology have focused on vasculitis-like anomalies or immune-mediated thrombosis in which viral alveolitis drives inflammation, endotheliopathy, and microvascular injury, leading to vascular tone dysregulation and pulmonary intravascular coagulopathy [5][6][7][8][9][10][11][12]. Postmortem reports and pathological specimens from COVID-19 patients showed DAD together with pulmonary infarction, small pulmonary vessel and capillary thrombosis, and hemorrhage [65,[67][68][69][70][71][72].…”

Section: Discussionmentioning

confidence: 99%

Automated Quantitative Lung CT Improves Prognostication in Non-ICU COVID-19 Patients beyond Conventional Biomarkers of Disease

Palumbo

Bruno

et al. 2021

Diagnostics

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(1) Background: COVID-19 continues to represent a worrying pandemic. Despite the high percentage of non-severe illness, a wide clinical variability is often reported in real-world practice. Accurate predictors of disease aggressiveness, however, are still lacking. The purpose of our study was to evaluate the impact of quantitative analysis of lung computed tomography (CT) on non-intensive care unit (ICU) COVID-19 patients’ prognostication; (2) Methods: Our historical prospective study included fifty-five COVID-19 patients consecutively submitted to unenhanced lung CT. Primary outcomes were recorded during hospitalization, including composite ICU admission for the need of mechanical ventilation and/or death occurrence. CT examinations were retrospectively evaluated to automatically calculate differently aerated lung tissues (i.e., overinflated, well-aerated, poorly aerated, and non-aerated tissue). Scores based on the percentage of lung weight and volume were also calculated; (3) Results: Patients who reported disease progression showed lower total lung volume. Inflammatory indices correlated with indices of respiratory failure and high-density areas. Moreover, non-aerated and poorly aerated lung tissue resulted significantly higher in patients with disease progression. Notably, non-aerated lung tissue was independently associated with disease progression (HR: 1.02; p-value: 0.046). When different predictive models including clinical, laboratoristic, and CT findings were analyzed, the best predictive validity was reached by the model that included non-aerated tissue (C-index: 0.97; p-value: 0.0001); (4) Conclusions: Quantitative lung CT offers wide advantages in COVID-19 disease stratification. Non-aerated lung tissue is more likely to occur with severe inflammation status, turning out to be a strong predictor for disease aggressiveness; therefore, it should be included in the predictive model of COVID-19 patients.

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“…Since its emergence, COVID-19 has baffled the world with its protean manifestations. Apart from the characteristic respiratory ailment, COVID-19 has wreaked havoc with its notorious thromboinflammatory complications, which are common in critically ill patients and associated with dismal prognosis [ 1 , 2 ]. From the cutaneous perspective, livedoid and necrotic eruptions were commonly observed finding in patients with more severe occlusive vascular disease [ 3 ].…”

Section: Introductionmentioning

confidence: 99%