Thrombotic and Hemostatic Aspects of Assisted Conception

Abstract

Assisted conception is a women's health issue of growing importance, with the number of women undergoing in vitro fertilization (IVF) increasing worldwide. IVF treatment involves ovarian stimulation that can result in a hyperestrogenic state, and in turn can lead to ovarian hyperstimulation syndrome (OHSS), which is associated with both venous and arterial thromboembolism. This chapter addresses clinically relevant thrombotic and hemostatic aspects of assisted conception, including the diagnosis, treatment and prevention of OHSS-related thromboembolism.

Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome

“…The advantages of IVM over conventional IVF include lower cost (because it does not need ovarian hyperstimulation), the absence of OHSS and less inconvenience for women [ 13 – 17 ]. Absence of OHSS is particularly relevant for women with PCOS who are at high risk of OHSS during ovarian hyperstimulation during conventional IVF, but also have an increased risk of ovarian torsion and thromboembolism associated with high estradiol levels [ 1 , 2 , 18 – 20 ]. Therefore, IVM is a useful technique for women with PCOS [ 21 ].…”