Thrombospondin-1 and prolyl 4-hydroxylase subunit alpha 3 as potential biomarkers of salivary gland fibrosis

Zhang, Zijian; Li, Honglin; Wang, Guanru; Zhao, Guile; Li, Chunjie; Cao, Yubin

doi:10.1016/j.jds.2023.02.009

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…This adhesive glycoprotein can influence platelet aggregation, angiogenesis, and tumorigenesis. [ 51 ] An in vivo experiment indicated that the clearance of THBS1 can mitigate the early stages of fibrogenesis, [ 52 ] possibly relating to the progress of MAFLD. PLA2G7 (phospholipase A2 group VII) is also called PAFAD, or LP-PLA2.…”

Section: Discussionmentioning

confidence: 99%

Demonstration of the impact of COVID-19 on metabolic associated fatty liver disease by bioinformatics and system biology approach

Huang,

Zheng,

Song

et al. 2023

Medicine

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Background: Severe coronavirus disease 2019 (COVID-19) has caused a great threat to human health. Metabolic associated fatty liver disease (MAFLD) is a liver disease with a high prevalence rate. Previous studies indicated that MAFLD led to increased mortality and severe case rates of COVID-19 patients, but its mechanism remains unclear. Methods: This study analyzed the transcriptional profiles of COVID-19 and MAFLD patients and their respective healthy controls from the perspectives of bioinformatics and systems biology to explore the underlying molecular mechanisms between the 2 diseases. Specifically, gene expression profiles of COVID-19 and MAFLD patients were acquired from the gene expression omnibus datasets and screened shared differentially expressed genes (DEGs). Gene ontology and pathway function enrichment analysis were performed for common DEGs to reveal the regulatory relationship between the 2 diseases. Besides, the hub genes were extracted by constructing a protein-protein interaction network of shared DEGs. Based on these hub genes, we conducted regulatory network analysis of microRNA/transcription factors–genes and gene - disease relationship and predicted potential drugs for the treatment of COVID-19 and MAFLD. Results: A total of 3734 and 589 DEGs were screened from the transcriptome data of MAFLD (GSE183229) and COVID-19 (GSE196822), respectively, and 80 common DEGs were identified between COVID-19 and MAFLD. Functional enrichment analysis revealed that the shared DEGs were involved in inflammatory reaction, immune response and metabolic regulation. In addition, 10 hub genes including SERPINE1, IL1RN, THBS1, TNFAIP6, GADD45B, TNFRSF12A, PLA2G7, PTGES, PTX3 and GADD45G were identified. From the interaction network analysis, 41 transcription factors and 151 micro-RNAs were found to be the regulatory signals. Some mental, Inflammatory, liver diseases were found to be most related with the hub genes. Importantly, parthenolide, luteolin, apigenin and MS-275 have shown possibility as therapeutic agents against COVID-19 and MAFLD. Conclusion: This study reveals the potential common pathogenesis between MAFLD and COVID-19, providing novel clues for future research and treatment of MAFLD and severe acute respiratory syndrome coronavirus 2 infection.

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Section: Discussionmentioning

confidence: 99%

Demonstration of the impact of COVID-19 on metabolic associated fatty liver disease by bioinformatics and system biology approach

Huang,

Zheng,

Song

et al. 2023

Medicine

View full text Add to dashboard Cite

show abstract

“…WB analysis was performed using the method previously described [ 21 , 22 ]. Total proteins from SMG tissues were extracted using RIPA lysis buffer (89,900, Thermo Fisher Scientific, Waltham, USA) following standard procedures.…”

Section: Methodsmentioning

confidence: 99%

TGF-β1 maintains the developmental potential of embryonic submandibular gland epithelia separated with mesenchyme

Li,

Wang,

Zhao

et al. 2024

Heliyon

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Blocking TSP1 Ameliorates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting the TGF-β/SMAD Pathway

Xia,

Yuan,

Fang

et al. 2024

World J Mens Health

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Thrombospondin-1 and prolyl 4-hydroxylase subunit alpha 3 as potential biomarkers of salivary gland fibrosis

Cited by 3 publications

References 21 publications

Demonstration of the impact of COVID-19 on metabolic associated fatty liver disease by bioinformatics and system biology approach

Demonstration of the impact of COVID-19 on metabolic associated fatty liver disease by bioinformatics and system biology approach

TGF-β1 maintains the developmental potential of embryonic submandibular gland epithelia separated with mesenchyme

Blocking TSP1 Ameliorates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting the TGF-β/SMAD Pathway

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