Thrombosis versus thermal coagulum formation as a result of endovenous laser treatment: Biochemistry versus photophysics

Heger, Michal

doi:10.1177/0268355513505507

Cited by 5 publications

(1 citation statement)

References 47 publications

(125 reference statements)

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“…In accordance with conclusions made in the study [30], we suggest that this effect is a result of the higher plasmonic efficiency of TiN and ZrN NP compared to Au NP and Ag NP. Laser heating of the RBC without structural changes is possible in the range of 37-70 • C, and spherocyte formation with following rupture can happen in the range of 70-94 • C [43]. Controlled application of laser irradiation can be used for optoporation of RBC for intracellular delivery.…”

Section: Discussionmentioning

confidence: 99%

Impact of Plasmonic Nanoparticles on Poikilocytosis and Microrheological Properties of Erythrocytes

et al. 2023

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Plasmonic nanoparticles (NP) possess great potential in photothermal therapy and diagnostics. However, novel NP require a detailed examination for potential toxicity and peculiarities of interaction with cells. Red blood cells (RBC) are important for NP distribution and the development of hybrid RBC-NP delivery systems. This research explored RBC alterations induced by noble (Au and Ag) and nitride-based (TiN and ZrN) laser-synthesized plasmonic NP. Optical tweezers and conventional microscopy modalities indicated the effects arising at non-hemolytic levels, such as RBC poikilocytosis, and alterations in RBC microrheological parameters, elasticity and intercellular interactions. Aggregation and deformability significantly decreased for echinocytes independently of NP type, while for intact RBC, all NP except Ag NP increased the interaction forces but had no effect on RBC deformability. RBC poikilocytosis promoted by NP at concentration 50 μg mL−1 was more pronounced for Au and Ag NP, compared to TiN and ZrN NP. Nitride-based NP demonstrated better biocompatibility towards RBC and higher photothermal efficiency than their noble metal counterparts.

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Section: Discussionmentioning

confidence: 99%

Impact of Plasmonic Nanoparticles on Poikilocytosis and Microrheological Properties of Erythrocytes

et al. 2023

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Endovascular laser–tissue interactions and biological responses in relation to endovenous laser therapy

et al. 2013

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Endovenous laser treatment (ELT) has evolved into a frequently employed modality for the treatment of leg varicose veins. Due to the very high complete response rates, minimal complications and side effects, and the possibility to monitor therapeutic outcome noninvasively by duplex ultrasound, a considerable amount of reports have been published on clinical and translational studies, whereas disproportionally few studies have been performed to elucidate the molecular and cellular basis for post-ELT vessel obliteration. Consequently, this review addresses the putative molecular and cellular mechanisms responsible for varicose vein obliteration following laser irradiation in the context of endovenous laser–tissue interactions. First, the histological profile of laser-treated varicose veins is summarized, and an account is given of the temporal and spatial dynamics of cells involved in inflammation and remodeling in the heat-affected vein segment. Inasmuch as thrombotic occlusion of the venous lumen blocks circulatory access to the affected vessel segment and thermal damage in the vascular wall causes most cells to die, the majority of cells involved in inflammation and remodeling have to be recruited. Second, the (possible) biochemical triggers for the chemotactic attraction of immune cells and fibroblasts are identified, comprising (1) thermal coagula, (2) thrombi, (3) dead and dying cells in the vein wall, and (4) thermally denatured extracellular matrix proteins in the vein wall. The molecular biology underlying the chemotactic signaling and subsequent obliterative remodeling is elucidated. Finally, the relative contribution of every biochemical trigger to obliterative remodeling is addressed.

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Experimental investigation on the transient vascular thermal response to laser irradiation by a high-speed infrared thermal camera

Wu,

Zhang,

Tao

et al. 2024

International Journal of Thermal Sciences

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Thrombosis versus thermal coagulum formation as a result of endovenous laser treatment: Biochemistry versus photophysics

Cited by 5 publications

References 47 publications

Impact of Plasmonic Nanoparticles on Poikilocytosis and Microrheological Properties of Erythrocytes

Impact of Plasmonic Nanoparticles on Poikilocytosis and Microrheological Properties of Erythrocytes

Endovascular laser–tissue interactions and biological responses in relation to endovenous laser therapy

Experimental investigation on the transient vascular thermal response to laser irradiation by a high-speed infrared thermal camera

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