Thrombosis in Ischemic Heart Disease

Increased thrombin-activatable fibrinolysis inhibitor antigen levels as a clue for prothrombotic state in polycystic ovary syndrome

“…A four-fold increase in the relative risk of myocardial infarction in postmenopausal women with a history of ovarian wedge resection for PCOS at age 40-49 years and an 11-fold increase at age 50-60 years were found in a retrospective study [16]. The impact of hypercoagulability on CVD is well established [29][30][31]. The suppression of fibrinolysis precedes CVD.…”

Effects of diet with or without exercise on leptin and anticoagulation proteins levels in obesity

“…In particular, the relative risk of death from cardiovascular disease (CVD) increases with increasing body mass index (BMI) [1]. Pathologically, thrombus formation triggered by fissured or disrupted atherosclerotic plaque is the principal step of CVD [2]. Disturbance of coagulation, fibrinolysis and endothelial function in obesity has been recognized as an important cause of the thromboembolic events [3][4][5].…”

Culprit only versus multivessel coronary revascularization in patients presenting with acute ST elevation myocardial infarction: Unending debate

“…As far as we know, myocardial infarction is associated with enhanced thrombotic and inflammatory states that may continue after AMI [8][9][10][11][12][13]. Thus, in the acute setting and in the immediate short-term after AMI, such an unfavorable thrombotic and inflammatory milieu compounded by multiple areas of vascular injury induced by multiple vessel intervention creates a high-risk situation in propensity for recurrent ischemic events and restenosis.…”