Thrombosis in an Internal Jugular Vein and an Upper Limb Deep Vein Treated with Edoxaban

Toratani, Mizuho; Hayashi, Akiko; Nakatani, Naoki; Nakamura, Hajime; Chida, Ryuji; Komatsu, Toshimitsu; Kobayashi, Shigeto; Tanaka, Isao

doi:10.2169/internalmedicine.56.7405

Cited by 11 publications

(13 citation statements)

References 11 publications

(12 reference statements)

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“…There were several common clinical signs ( Table 1 ). The most frequent were neck swelling and erythema [ 2 , 3 , 5 , 6 , 11 , 12 , 13 , 14 , 15 , 17 , 23 , 24 , 25 , 26 , 27 ] and the palpable cord beneath the sternocleidomastoid muscle [ 2 , 3 , 6 , 28 ], frequently associated with fever [ 3 , 14 , 18 , 28 ]. Oedematous swelling of the face/scalp [ 17 , 18 , 26 , 29 , 30 ], papilledema [ 12 , 14 , 17 , 22 ] and intracranial hypertension [ 9 , 12 , 14 , 22 , 28 ] were also reported in several papers.…”

Section: Resultsmentioning

confidence: 99%

Internal Jugular Vein Thrombosis: Etiology, Symptomatology, Diagnosis and Current Treatment

et al. 2021

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(1) Background: internal jugular vein thrombosis (IJVthr) is a potentially life-threating disease but no comprehensive reviews on etiology, symptomatology, diagnosis and current treatment guidelines are yet available; (2) Methods: we prospectively developed a protocol that defined objectives, search strategy for study identification, criteria for study selection, data extraction, study outcomes, and statistical methodology, according to the PRISMA standard. We performed a computerized search of English-language publications listed in the various electronic databases. We also retrieved relevant reports from other sources, especially by the means of hand search in the Glauco Bassi Library of the University of Ferrara; (3) Results: using the predefined search strategy, we retrieved and screened 1490 titles. Data from randomized control trials were few and limited to the central vein catheterization and to the IJVthr anticoagulation treatment. Systematic reviews were found just for Lemierre syndrome, the risk of pulmonary embolism, and the IJVthr following catheterization. The majority of the information required in our pre-defined objectives comes from perspectives observational studies and case reports. The methodological quality of the included studies was from moderate to good. After title and abstract evaluation, 1251 papers were excluded, leaving 239 manuscripts available. Finally, just 123 studies were eligible for inclusion. We found out the description of 30 different signs, symptoms, and blood biomarkers related to this condition, as well as 24 different reported causes of IJVthr. (4) Conclusions: IJVthr is often an underestimated clinical problem despite being one of the major sources of pulmonary embolism as well as a potential cause of stroke in the case of the upward propagation of the thrombus. More common symptoms are neck pain and headache, whereas swelling, erythema and the palpable cord sign beneath the sternocleidomastoid muscle, frequently associated with fever, are the most reported clinical signs. An ultrasound of the neck, even limited to the simple and rapid assessment of the compression maneuver, is a quick, economic, cost-effective, noninvasive tool. High quality studies are currently lacking.

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Section: Resultsmentioning

confidence: 99%

Internal Jugular Vein Thrombosis: Etiology, Symptomatology, Diagnosis and Current Treatment

et al. 2021

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“…Secondary UEDVT accounts for up to 80% of UEDVT and is defined as any UEDVT associated with a predisposing factor, such as central venous catheters, implantable cardiac rhythm devices, malignancy, or insertion of other prosthetic or foreign material [5]. Other related risk factors include personal or family history of thrombosis and thrombophilia, surgery, trauma or immobilization of the arm, pregnancy and oral contraceptive use [6].…”

Section: Discussionmentioning

confidence: 99%

Internal Jugular and Subclavian Vein Thrombosis in a Post-liver Transplant Patient

Algoblan

AlAitah

Alotaibi

2020

Cureus

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Internal jugular vein thrombosis (IJVT) is an unusual case of vascular disease of the upper limb veins, that could result in multiple complications if left untreated. IJVT can be subdivided into primary and secondary. Primary IJVT is when the thrombosis happens to someone without known risk factors, while secondary IJVT is when it happens to a person with previous risk factors. Our patient is a 66-year-old male with a history of hypertension and is status post-liver transplant in 2014 due to end-stage liver disease; he presented to the emergency department of the King Faisal Specialist Hospital & Research Center complaining of progressive right chest, flank, and back pain for the past month. On physical examination, the patient had right upper limb, chest, and neck increase in vascular markings and right supraclavicular swelling with no erythema. Upper extremity and neck ultrasound showed positive deep vein thrombosis (DVT) of the right internal jugular vein, right subclavian vein, and axillary vein. A chest X-ray showed right-sided pleural effusion with no mediastinal shift. Computer tomography (CT) demonstrated thrombosed right internal jugular and subclavian veins. General internal medicine service was consulted and they started the patient on Emxparine 1 mg/kg twice daily. The patient improved and is doing fine. He is scheduled for repeated outpatient followups.

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“…Few reports of using edoxaban for IJVT have been published. Toratani et al started edoxaban after 7 days' administration of heparin 10,000 units/day for the idiopathic left internal jugular vein, left subclavian vein, and left brachial vein thrombosis [9]. They reported relief of the swelling and no bleeding complications.…”

Section: Discussionmentioning

confidence: 99%

Disappearance of Internal Jugular Vein Thrombosis After Use of Edoxaban Following Head and Neck Reconstruction: A Case Report

Shibuya¹,

Nishijima²,

Oshima³

et al. 2020

JSO

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Internal jugular vein thrombosis (IJVT) is a complication of neck dissection. After head and neck reconstruction, flap congestion due to IJVT may lead to flap necrosis, and early diagnosis and treatment should be considered. We experienced a case of disappearance of IJVT in which edoxaban was administered after free-flap reconstruction, and the entire flap survived. Edoxaban has few bleeding complications and was useful as a single drug approach for IJVT after head and neck reconstruction.

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Thrombosis in an Internal Jugular Vein and an Upper Limb Deep Vein Treated with Edoxaban

Cited by 11 publications

References 11 publications

Internal Jugular Vein Thrombosis: Etiology, Symptomatology, Diagnosis and Current Treatment

Internal Jugular Vein Thrombosis: Etiology, Symptomatology, Diagnosis and Current Treatment

Internal Jugular and Subclavian Vein Thrombosis in a Post-liver Transplant Patient

Disappearance of Internal Jugular Vein Thrombosis After Use of Edoxaban Following Head and Neck Reconstruction: A Case Report

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