Thrombosis as a Complication of Inflammatory Bowel Disease in Children

Thromboembolism in pediatric inflammatory bowel disease: Systematic review

“…In all 185 articles were excluded as they did not concern TE events in children or were not original reports. In total, two historical cohort studies, 5,7 five retrospective analysis of single hospital databases, [12][13][14][15][16] eight case series, [17][18][19][20][21][22][23][24] and thirty-six case-reports were retrieved (Fig. 1).…”

“…Apart from the 8/70 (11.4%) children with early TE recurrence within the same hospitalization, 12,15,18,30,36-38 7/ 70 (10%) experienced a separate TE recurrence, 17,18,20,28,29,40 with two presenting more than one recurrence. 29,40 The interval between the first and the second episode of TE ranged from 1 month to some years.…”

“…Eight case series [17][18][19][20][21][22][23][24] and 36 single case-reports were retrieved, accounting for a total of 70 children with TE in IBD. The characteristics of children with thrombosis during IBD are reported in Table 3.…”

Portal vein thrombus after pediatric proctocolectomy with ileoanal anastomosis

“…In a retrospective review of 180 patients with IBD evaluated between 1975 and 1987, Lloyd-Still and Tomasi [16] identified 6 patients with known thromboembolic complications for an incidence of 3.3% in their IBD population. Lower extremity deep venous thrombosis and thromboembolic cerebrovascular accidents are the most well-documented thrombotic events in the pediatric IBD population [2,[16][17][18]. There is one case report of BuddChiari syndrome in a 14-year-old patient with known ulcerative colitis [19].…”

Venous thromboembolism with infl ammatory bowel disease

“…Moreover, thromboembolism appears to develop with inflammatory bowel disease at a younger age [7] . Finally, thrombosis has also been reported in children with inflam-matory bowel disease [8] .…”