Thromboprophylaxis for trauma patients

Barrera, L.; Perel, Pablo; Ker, Katharine; Cirocchi, Roberto; Farinella, Eriberto; Uribe, Carlos Hernándo Morales

doi:10.1002/14651858.cd008303.pub2

Cited by 127 publications

(133 citation statements)

References 47 publications

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“…In a metaanalysis done to evaluate VTE prophylaxis in trauma patients, researchers reported that patients who received both had a lower risk of DVT. 34 Results of another meta-analysis done to examine VTE prevention in hospitalized patients also indicated that pharmacological prophylaxis combined with IPC was more effective than IPC alone. 25 Results of recent RCTs in critically ill patients also suggest that combination therapy is superior to either pharmacological or mechanical prophylaxis alone.…”

Section: Supporting Evidencementioning

confidence: 99%

Preventing Venous Thromboembolism in Adults

2016

Critical Care Nurse

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Section: Supporting Evidencementioning

confidence: 99%

Preventing Venous Thromboembolism in Adults

2016

Critical Care Nurse

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“…Efficacy of LMWH was compared with UFH in trauma patients among two RCTs. No statistically significant difference in the risk of VTE or risk of bleeding has been reported between the groups [69]. Trauma patients especially neurotrauma individuals are at highest risk for VTE and needed both prophylaxis and close surveillance for VTE events [56].…”

Section: Traumamentioning

confidence: 99%

Heparin and related drugs for venous thromboembolism prophylaxis: subcutaneous or intravenous continuous infusion?

et al. 2015

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In this article, the most evidenced approaches of unfractionated heparin administration for prevention of venous thromboembolism in medical and surgical hospitalized patients will be reviewed. Present data were collected by searching Scopus, PubMed, MEDLINE, Science direct, Clinical trials and Cochrane database systematic reviews. Subcutaneous low doses of unfractionated heparin (10000-15000 IU) in two or three divided doses per day are commonly administrated for venous thromboembolism prevention in different medical and surgical populations. In some populations such as obese surgical and critically ill patients, due to altered pharmacokinetics behavior of unfractionated heparin, continuous intravenous infusion of the low doses of unfractionated heparin has been proposed.

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“…Prothrombotic changes in physiology are hypothesised to occur within 48 hours following trauma 4. Chemical VTE prophylaxis is superior to mechanical VTE prophylaxis 5. Mechanical prophylaxis may be precluded in blunt trauma if there is associated lower limb injury.…”

Section: Commentsmentioning

confidence: 99%

BET 2: Is early chemical thromboprophylaxis safe in patients with blunt trauma solid organ injury (SOI) undergoing non-operative management (NOM)?

Ferguson

Lewin

2018

Emerg Med J

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A short cut review was carried out to establish whether chemical thromboprophylaxis was a safe early intervention in patients with solid organ injury that is being managed non-operatively. Eight papers presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. It is concluded that there is inadequate evidence assessing safety of low molecular weight heparin (LMWH) within 24 hours of trauma. The current available evidence does suggest that administration of LMWH within 48 hours is safe in non-operative management of patients who have sustained solid organ injury from blunt trauma.

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Thromboprophylaxis for trauma patients

Cited by 127 publications

References 47 publications

Preventing Venous Thromboembolism in Adults

Preventing Venous Thromboembolism in Adults

Heparin and related drugs for venous thromboembolism prophylaxis: subcutaneous or intravenous continuous infusion?

BET 2: Is early chemical thromboprophylaxis safe in patients with blunt trauma solid organ injury (SOI) undergoing non-operative management (NOM)?

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