Thromboprophylaxis and maternal-fetal outcomes of women with serum markers for hereditary thrombophilia and previous obstetric complications

Ferreira, Cristiane Munaretto; Figueiró-Filho, Ernesto Antônio; Oliveira, Vanessa Marcon de; Pereira, Érica Freire de Vasconcelos

doi:10.1590/1806-93042017000400005

Cited by 1 publication

(2 citation statements)

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“…Some guidelines do not support the search for serum markers for this pathology unless there is a previous personal / family history of thromboembolism. However, HT investigation in women with a history of obstetric complications is helpful in clinical management in gynecology and obstetrics services [8] .…”

Section: Disease Diagnosismentioning

confidence: 99%

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Gestational Thrombophilia

Casseb¹,

Casseb²,

Souza³

et al. 2022

Int J Innov Educ Res

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The woman's body undergoes several physiological changes during the gestational period. Risk factors and comorbidities can cause pathophysiological changes in this period, especially in the maternal vascular system, triggering thrombophilia. This clotting disorder increases the thrombus formation risk, especially in the uteroplacental circulation. The study aimed to conduct a thorough review of the main approaches to diagnosis and treatment in reducing patient morbidity and mortality. This is an integrative review with qualitative data searched in Pubmed, BVS and Cochrane Library. A total of 624 studies were found, 591 were excluded outside the inclusion criteria, and 33 were selected. According to the careful search, thrombophilias can be hereditary or acquired, the former when there is a predisposition to venous occlusion and the latter from other clinical conditions. Pregnancy is a pro-thrombotic event and increases the chances of thrombus occurrence, triggering a series of pregnancy complications, such as intrauterine death, early or late miscarriage, and premature birth. However, if diagnosed early, there is a favorable prognosis for the woman and the fetus. To reduce these impacts of gestational thrombophilia, it is imperative to train primary health care and private clinics professionals to promote and treat health and basic diagnostic tests on pregnant women. Thus, performing early intervention avoiding the development of maternal-fetal complications.

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Section: Disease Diagnosismentioning

confidence: 99%

“…Thus, screening for thrombophilia is necessary for pregnant women with one or more clinical problems and a history of thromboembolism due to an apparent risk factor. For this reason, surveillance and investigation of symptoms are essential for prompt treatment initiation [8] .…”

Section: Introductionmentioning

confidence: 99%