Thrombopoietin promotes hematopoietic recovery and survival after high-dose whole body irradiation

Recombinant human thrombopoietin: basic biology and evaluation of clinical studies

“…145,146 Similar results have been noted in subsequent studies that investigated the effect of rhTPO in mice exposed to lethal doses of TBI. 147 Almost all the mice that received rhTPO close to the time of irradiation survived, whereas all the mice that received placebo died within 30 days of receiving TBI. Furthermore, recovery of blood counts in all lineages improved in those mice that received rhTPO within several hours of TBI.…”

Different Radiosensitive Megakaryocytic Progenitor Cells Exist in Steady-State Human Peripheral Blood

“…Information taken from its package insert indicates that when administered to irradiated rhesus macaques at 150 U/kg daily for 20 days, TPIAO increased platelet counts and shortened the duration of thrombocytopenia. A number of animal studies confirm this finding by demonstrated that recombinant, full-length forms of human or animal TPO, given alone (32)(33)(34)(35)(36)(37)(38) or in combination with other drugs (28,29,37,(39)(40)(41) or bone marrow transplant (29,43), increase platelet counts and/or improve survival after an acute, total-body radiation exposure. Recent data suggest that TPIAO will have similar efficacy in an animal model (Y. Wei).…”

Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages

“…[28][29][30] This phenomenon suggests that HAPO may act on a relatively rare cell population and that therefore a larger amount of HAPO is needed for activation of the targeted cells. Another possibility is that HAPO may be a unique growth factor because the normal serum level of HAPO (56.42 Ϯ 14.26 ng/mL) measured in our laboratory (ranging from 18.3 ng/mL to 91.1 ng/mL; n ϭ 46; data not shown), by means of a sandwich enzyme-linked immunosorbent assay (ELISA), was found to be relatively higher than that of SCF, TPO, G-CSF, or FLT-3 ligand in normal serum.…”