Thrombopoietin levels increased in patients with severe acute respiratory syndrome

Yang, Mei; Ng, Margaret H.L.; Li, Chi Kong; Chan, Paul K.S.; Liu, Chang; Ye, Jie Yu; Chong, Beng H.

doi:10.1016/j.thromres.2007.12.021

Cited by 38 publications

(39 citation statements)

References 22 publications

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“…Yang et al [13] have reported the increased thrombopoietin and thrombocyte counts in the SARS disease. Also, Vlacha and collegues have reported that the thrombocytosis had occured in serious lower respiratory tract infections [14].…”

Section: Discussionmentioning

confidence: 99%

Finding Thrombocytosis at the Time of the Diagnosis in the Patients With Pneumonia, Bronchiolitis and Asthma, and Its Importance in Terms of the Diagnosis

Aydemir¹,

Sezer²,

Barış³

2012

Pediatr Therapeut

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Introduction: The aim of our study is to evaluate thrombocytosis at the time of the diagnosis in the patients with pneumonia, bronchiolitis and asthma, and its importance in terms of the diagnosis. Materials and Methods: We evaluated 583 patients diagnosed as asthma (n=36), bronchiolitis (n=387) and pneumonia (n=160) in pediatry clinic of GATA Haydarpasa Training Hospital and Zeynep Kamil Research Hospital between January 1, 2007 and January 1, 2010; and the ratio of patients with thrombocytosis at the time of diagnosis retrospectively. Results: We found that the mean thrombocyte counts in patients who had been diagnosed as pneumonia and as bronchiolitis were found significantly higher than control group (p<0.05). But, there wasn't a significant difference between the patients with asthma and control group (p=0.77). Otherwise, the number of patiens who have thrombocytosis with pneumonia and bronchiolitis were significantly higher than control group (p<0.005). But there wasn't a significant difference in chronic asthma group (p=0.81). Conclusion: Our study supports that, the thrombocyte counts are also another parameters that can help while making the diagnosis of the infectious pulmonary pathologies.

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Section: Discussionmentioning

confidence: 99%

Finding Thrombocytosis at the Time of the Diagnosis in the Patients With Pneumonia, Bronchiolitis and Asthma, and Its Importance in Terms of the Diagnosis

Aydemir¹,

Sezer²,

Barış³

2012

Pediatr Therapeut

View full text Add to dashboard Cite

show abstract

“…Consumptive coagulopathy is a typical feature in SIC/ DIC; however, that type of coagulopathy is usually not seen in COVID-19 in its early phase. IL-1β and IL-6 are known to induce thrombocytosis and hyperfibrinogenemia, and sustained inflammation may stimulate the production of these factors [21]. In addition, inflammation and coagulation are localized within the lung in early stages but with disease progression, hypercoagulability becomes systemic and proceeds towards SIC/DIC.…”

Section: Sepsis-induced Coagulopathy (Sic) and Disseminated Intravascmentioning

confidence: 99%

The unique characteristics of COVID-19 coagulopathy

et al. 2020

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Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC), with CAC usually showing increased D-dimer and fibrinogen levels but initially minimal abnormalities in prothrombin time and platelet count. Venous thromboembolism and arterial thrombosis are more frequent in CAC compared to SIC/DIC. Clinical and laboratory features of CAC overlap somewhat with a hemophagocytic syndrome, antiphospholipid syndrome, and thrombotic microangiopathy. We summarize the key characteristics of representative coagulopathies, discussing similarities and differences so as to define the unique character of CAC.

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“…[17] In severe acute respiratory syndrome induced by a novel coronavirus, TGFb inhibits the effect of high TPO on megakaryocytopoiesis. [18] Inflammatory mediator interleukin 6 (IL-6), however, increases TPO production both in vitro and in vivo. [14] Our finding of high TPO during acute PUUV infection is in line with a previous observation [9] and consistent with both low platelet count and high plasma IL-6 in acute PUUV infection .…”

Section: Discussionmentioning

confidence: 99%

Elevated thrombopoietin and platelet indices confirm active thrombopoiesis but fail to predict clinical severity of puumala hantavirus infection

et al. 2016

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We evaluated the mechanisms of thrombocytopenia and procoagulant changes in relation with clinical variables in a cohort of patients with acute hantavirus disease.Blood samples of 33 prospectively recruited, consecutive, hospitalized patients with acute Puumala virus–induced hemorrhagic fever with renal syndrome (HFRS) were collected acutely and at the recovery visit (control). Serum thrombopoietin (TPO) and activity of plasma microparticles (MPs) from various cell sources were measured with enzyme-linked immunosorbent assay-based methods. The results were related to data on platelet indices and functions, coagulation variables, and clinical disease.Serum TPO was nearly 4-fold higher acutely compared with the control (median 207 pg/mL, range 56–1258 pg/mL vs. median 58 pg/mL, range 11–241 pg/mL, P < 0.001) and coincided with high mean platelet volume (MPV) and immature platelet fraction (IPF%). Prothrombin fragments and D-dimer were high acutely compared with the control (F1 + 2 median 704 pmol/L, range 284–1875 pmol/L vs. median 249 pmol/L, range 118–556 pmol/L, P < 0.001; d-dimer median 2.8 mg/L, range 0.6–34.0 mg/L vs. median 0.4 mg/L, range 0.2–1.1 mg/L, P < 0.001), and associated with low platelet count and severe acute kidney injury (AKI). MPs’ procoagulant activity was high acutely only among patients with mild AKI (plasma creatinine below the median at the time of the measurement).Upregulated TPO together with high MPV and IPF% confirm active thrombopoiesis, but do not predict severity of HFRS. Simultaneously, elevated prothrombin fragments and d-dimer suggest increased consumption of platelets in patients with severe AKI. Activity of platelet-derived MPs in HFRS should be studied with flow cytometry in a larger cohort of patients.

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Thrombopoietin levels increased in patients with severe acute respiratory syndrome

Cited by 38 publications

References 22 publications

Finding Thrombocytosis at the Time of the Diagnosis in the Patients With Pneumonia, Bronchiolitis and Asthma, and Its Importance in Terms of the Diagnosis

Finding Thrombocytosis at the Time of the Diagnosis in the Patients With Pneumonia, Bronchiolitis and Asthma, and Its Importance in Terms of the Diagnosis

The unique characteristics of COVID-19 coagulopathy

Elevated thrombopoietin and platelet indices confirm active thrombopoiesis but fail to predict clinical severity of puumala hantavirus infection

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