Thromboplastic and Fibrinolytic Activities in Vessels of Animals

Abstract

Thromboplastic activity and concentration of plasminogen activator were assayed in the coats of arteries and veins from a number of species. The widely differing patterns found in these species suggest great variation in the tendency to deposit fibrin on the interior surface of the vessels. Several modes of regulating fibrin deposition after intimal injury exist in the animal organism. These observations may assist the evaluation of data obtained in experiments on animals, and they demonstrate certain limitations with respect to conclusions on pathology in man.

Fibrinolytic Activity in Human Atherosclerotic Coronary Arteries

“…• Assays of thromboplastic and fibrinolytic activities of extracts of the layers of the normal arterial wall of animals and man have been reported (1)(2)(3)(4). In man the aortic intima is rich in thromboplastin with little or no fibrinolytic activity suggesting that fibrin formation may occur readily while fibrin resolution is delayed.…”

The Role of Endothelial Cells and Subendothelial Components in the Initiation of Blood Coagulation

“…Studies of the effect of intracellular activities from the endothelial cells have been carried out (15,16), but the interpretation of the these studies have been ambiguous since the assays used have failed to distinguish between the extrinsic tissue factor activity and possible activators of the intrinsic system. In the present study, which is only a preliminary work, the problem of interference by tissue factor activity was solved by incubating the endothelial cells with anti body to the apoprotein of tissue factor.…”

Deep-vein thrombosis.

“…Normal veins are a potent source of a plasminogen activator substance, 22 and it has been suggested that peripheral thrombolysis may be under neurogenic control.23 This property may play a part in preventing thrombosis and encouraging recannulation after thrombosis. 24 What -can the future hold ?…”