Thrombophilia in Patients with Retinal Vein Occlusion: A Retrospective Analysis

Abstract

Background: To assess the prevalence of thrombophilia in patients with central (CRVO) and branch retinal vein occlusion (BRVO). Methods: In 139 patients with CRVO (n = 88) and BRVO (n = 51) and in 40 healthy controls factor VIII, fibrinogen, antithrombin III, protein C, protein S, activated protein C resistance, anticardiolipin antibodies (ACA), homocysteine, factor V Leiden, prothrombin G20210A and methylene tetrahydrofolate reductase (MTHFR) C677T mutation were assessed retrospectively. Results: Elevated factor VIII activity and the homozygous MTHFR C677T mutation were significantly more often found in CRVO and BRVO cases compared to controls. Age-, gender- and C-reactive protein-adjusted logistic regression analysis did not show a significant additive effect of elevated factor VIII activity on the risk of developing CRVO/BRVO. Elevated fibrinogen levels and ACA were significantly more often found in CRVO than amongst controls. No significant differences were found concerning the remaining variables. Conclusions: We suggest elevated fibrinogen levels, ACA and the homozygous MTHFR C677T mutation as potential risk factors for CRVO/BRVO.

Risk of Retinal Vein Occlusion in Patients With End-Stage Renal Disease: A 12-Year, Retrospective, Nationwide Cohort Study in South Korea

“…[36][37][38] Dysregulation of coagulation and anticoagulation is reported as a major risk factor for RVO. 12,21,39,40 Moreover, acquired or genetic thrombophilia can increase the risk of RVO. 39,40 A number of recent studies have also demonstrated that inflammation plays an important role in the onset and progression of RVO.…”

Branch Retinal Vein Occlusion

“…Similarly, Demirci et al [ 54 ] in their study found no clear association between retinal vein occlusion and factor V Leiden in this pool of patients and concluded that factor V Leiden does not seem to play an important role in the development of retinal vein occlusion. Risse et al [ 55 ] in a study of 51 patients with BRVO on age-, gender-, and C-reactive protein-adjusted logistic regression analysis did not fi nd a signifi cant additive effect of elevated factor VIII activity on the risk of developing BRVO. Mrad et al [ 56 ] in 68 patients with BRVO found no statistically signifi cant differences in the frequencies of the prothrombin G20210A polymorphism between the BRVO group and healthy controls.…”

No evidence for thrombophilia in patients with retinal venous occlusion: a systematic GRADE‐based review

“…One study reported significantly more patients who were homozygote for the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene in the case group compared with the control group (Risse et al. ), and two small studies reported an association with protein C deficiency and RVO (Tekeli et al. ; Ates ).…”