Thrombophilia in hepatocellular carcinoma

Selim, Fayrouz Othman; Abdalla, Taghrid Mohamed; Hosny, Thoraya

doi:10.1186/s43066-019-0003-x

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…CLD starts with liver infl ammation that may progress to diff erent degrees of liver fi brosis, cirrhosis, and Hepatocellular Carcinoma (HCC) [11,12]. Indeed, CLD and liver cancer can cause disturbances in the coagulation system [13]. The imbalance in the coagulation factors, including procoagulants and anticoagulants, in CLD may have clinical implications, with PVT as a possible complication in hepatic cirrhosis [14].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Factor V Gene G1691A Mutation (Factor V Leiden) among Chronic Hepatitis C Patients with Thrombocytopenia

Khedr¹,

Barakat²,

Salama³

2022

J Biomed Res Environ Sci

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Background: Factor V plays a crucial role in the coagulation process. Factor V Leiden (FVL) is considered a mutant form of factor V, which may contribute to blood vessel thrombosis. Also, Hepatitis C Virus (HCV) infection may exert some coagulation changes leading to Portal Vein Thrombosis (PVT). Thrombocytopenia in patients with chronic HCV infection constitutes a major challenge. Objective: This study aimed to investigate the incidence of FVL (factor V gene G1691A mutation) and its influence on coagulation among HCV chronically infected patients suffering from thrombocytopenia. Besides, it was designed to demonstrate the association of chronic HCV infection with coagulation disturbances in such patients. Methods: This study was conducted on blood samples of a total of 54 subjects (33 HCV chronically infected patients and 21 healthy controls). HCV chronically infected patients with thrombocytopenia (Platelet Count [PLC] below 150 thousand/microliter) were selected. Prothrombin Time (PT) and Activated Partial Thromboplastin Time (aPPT) were previously determined as coagulation parameters. Protein C and protein S antigens were determined by ELISA as coagulation-regulating (anticoagulants) parameters. All samples were investigated for the presence of FVL by real-time PCR. Results: PLC, PT, and protein C antigen showed highly significant differences (p < 0.001) between controls (group 1) and HCV chronically infected patients (group 2). Likewise, a highly significant change (p = 0.006) was achieved for the protein S antigen. A non-significant change was detected for the incidence of FVL with a heterozygous pattern between controls (group 1) and HCV chronically infected patients (group 2). Additionally, non-significant changes were detected for all of the investigated coagulation and coagulation-regulating (anticoagulants) parameters between control subjects with negative FVL (subgroup 1) and others with positive FVL (subgroup 2). Similarly, non-significant changes for such parameters were recoded for HCV chronically infected patients with negative FVL (subgroup 3) and others with positive FVL (subgroup 4). Conclusion: Chronic HCV infection in the presence of thrombocytopenia is associated with coagulation disturbances. The incidence of FVL with its heterozygous pattern is unaffected by chronic HCV infection, and no association is shown with worsening of coagulation in chronic hepatitis C patients suffering from thrombocytopenia.

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Section: Introductionmentioning

confidence: 99%

Assessment of Factor V Gene G1691A Mutation (Factor V Leiden) among Chronic Hepatitis C Patients with Thrombocytopenia

Khedr¹,

Barakat²,

Salama³

2022

J Biomed Res Environ Sci

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“…The presence of HCC per se predisposes to thrombophilia, and this needs to be investigated separately. 8 Overall, the authors must be commended for carrying out this innovative meta-analysis, which should prove to be a stepping stone for further research into the use of anticoagulation in patients with cirrhosis and non-malignant PVT.…”

mentioning

confidence: 99%

Portal vein thrombosis in cirrhosis: exploring the uncharted waters

Anirvan

2023

J of Gastro and Hepatol

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Thrombophilia in hepatocellular carcinoma

Cited by 2 publications

References 31 publications

Assessment of Factor V Gene G1691A Mutation (Factor V Leiden) among Chronic Hepatitis C Patients with Thrombocytopenia

Assessment of Factor V Gene G1691A Mutation (Factor V Leiden) among Chronic Hepatitis C Patients with Thrombocytopenia

Portal vein thrombosis in cirrhosis: exploring the uncharted waters

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