Thrombomodulin serum levels in ventilated preterm babies with respiratory distress syndrome

Distefano, Giuseppe; Romeo, Mario; Betta, Pasqua; Rodonò, A; Amato, Maurizio

doi:10.1007/s004310050821

Cited by 16 publications

(14 citation statements)

References 20 publications

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“…Plasma TM levels were not elevated in preterm infants before the development of respiratory distress syndrome (RDS) [22] and therefore did not serve as a predictive marker. However, after the development of RDS, plasma TM levels or preterm babies with RDS were significantly elevated as compared with those in babies without pulmonary disease [23]. Additionally, levels in babies with severe RDS were found to be significantly higher than in those with moderate RDS [23].…”

Section: Discussionmentioning

confidence: 85%

“…However, after the development of RDS, plasma TM levels or preterm babies with RDS were significantly elevated as compared with those in babies without pulmonary disease [23]. Additionally, levels in babies with severe RDS were found to be significantly higher than in those with moderate RDS [23]. Although plasma TM levels have been found to be elevated due to endothelial injury in ARDS [24,25], no studies to date have reported on the usefulness of plasma TM levels in predicting the occurrence of acute lung injury in adults at risk.…”

Section: Discussionmentioning

confidence: 86%

See 1 more Smart Citation

Plasma levels of the three endothelial-specific proteins von Willebrand factor, tissue factor pathway inhibitor, and thrombomodulin do not predict the development of acute respiratory distress syndrome

Bajaj

Tricomi

1999

Intensive Care Medicine

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 86%

Plasma levels of the three endothelial-specific proteins von Willebrand factor, tissue factor pathway inhibitor, and thrombomodulin do not predict the development of acute respiratory distress syndrome

Bajaj

Tricomi

1999

Intensive Care Medicine

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“…18 There is a need in neonatology for a specific and sensitive test that would allow the identification of myocardial cell damage in either isolated conditions or associated with other pathologic conditions. 19 In sick infants, myocardial stunning may be responsible for some of the cardiovascular insufficiency seen in the neonatal period. If this stunning is due to myocardial ischemia, it may be reflected in elevated cardiac TnI levels.…”

Section: Discussionmentioning

confidence: 99%

Troponin I as a Biomarker of Cardiac Injury in Neonates with Idiopathic Respiratory Distress

Distefano¹,

Sciacca²,

Mattia³

et al. 2006

Amer J Perinatol

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Troponin I (TnI), an inhibitory protein complex located on the actin filament of cardiac muscle, has become a specific marker of myocardial damage. Troponin has been studied in a wide range of clinical settings. However, many questions are still unanswered, especially in preterm neonates with the most common pathology at birth, such as idiopathic respiratory distress syndrome (IRDS). The aim of this study was to establish a reference range for cardiac TnI for healthy preterm infants and serum levels in sick preterm infants with IRDS. Echocardiography was performed and TnI serum levels were measured at a median age of 62 hours of life in three groups of healthy preterm infants (n = 10), and ventilated infants with moderate (n = 15) and severe IRDS (n = 15). Ventilated infants with idiopathic moderate IRDS had significantly different cardiac parameters (R/L ejection fraction, R/L stroke volume, R/L cardiac output; p < 0.05) and significantly higher cardiac TnI levels than healthy infants (0.037 versus 0.01 microg/mL; p < 0.05). Furthermore, infants with severe IRDS had higher TnI concentrations than infants with moderate IRDS (0.26 versus 0.037 microg/mL; p < 0.05). The results of this study show that increased TnI serum levels in sick preterm infants with IRDS are explained by myocardial injury or dysfunction due to impaired arterial oxygenation or reduction in cardiac output during treatment with mechanical ventilation. These results suggest that cardiac TnI may be a useful, specific marker for myocardial damage in preterm neonates with IRDS.

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“…The PC system is markedly disrupted in patients with ARDS and plasma TM is increased in ARDS patients, possibly through proteolytic release from the injured pulmonary endothelium [202,203]. Similarly, plasma TM is increased in infants with respiratory distress syndrome, especially in those treated with mechanical ventilation [204], while elevated plasma soluble (s)TM levels were associated with organ dysfunction in children with ARDS and with higher mortality in children with indirect lung injury [205]. Soluble TM in BALF was found to be an independent predictor of severe drug-induced lung injury [206], and moreover, higher plasma sTM levels were associated with increased mortality in ARDS [207].…”

Section: Coagulationmentioning

confidence: 99%

Endothelial Damage in Acute Respiratory Distress Syndrome

Vassiliou

Κοτανίδου

Dimopoulou

et al. 2020

IJMS

154

104

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The pulmonary endothelium is a metabolically active continuous monolayer of squamous endothelial cells that internally lines blood vessels and mediates key processes involved in lung homoeostasis. Many of these processes are disrupted in acute respiratory distress syndrome (ARDS), which is marked among others by diffuse endothelial injury, intense activation of the coagulation system and increased capillary permeability. Most commonly occurring in the setting of sepsis, ARDS is a devastating illness, associated with increased morbidity and mortality and no effective pharmacological treatment. Endothelial cell damage has an important role in the pathogenesis of ARDS and several biomarkers of endothelial damage have been tested in determining prognosis. By further understanding the endothelial pathobiology, development of endothelial-specific therapeutics might arise. In this review, we will discuss the underlying pathology of endothelial dysfunction leading to ARDS and emerging therapies. Furthermore, we will present a brief overview demonstrating that endotheliopathy is an important feature of hospitalised patients with coronavirus disease-19 (COVID-19).

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Thrombomodulin serum levels in ventilated preterm babies with respiratory distress syndrome

Abstract: These data show that TM can be used as marker of pulmonary endothelial damage in preterm babies treated with mechanical ventilation for RDS and suggest early intervention with exogenous surfactant to limit alveolar protein leakage and surfactant inactivation.

Cited by 16 publications

References 20 publications

Plasma levels of the three endothelial-specific proteins von Willebrand factor, tissue factor pathway inhibitor, and thrombomodulin do not predict the development of acute respiratory distress syndrome

Plasma levels of the three endothelial-specific proteins von Willebrand factor, tissue factor pathway inhibitor, and thrombomodulin do not predict the development of acute respiratory distress syndrome

Troponin I as a Biomarker of Cardiac Injury in Neonates with Idiopathic Respiratory Distress

Endothelial Damage in Acute Respiratory Distress Syndrome

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