Abstract:Substantial thrombomodulin activity could be detected in tissue thromboplastin preparations from placenta or from lung but not from brain. When the amount of these preparations was adjusted to contain 1 unit of tissue factor activity, up to 0.85 units of thrombomodulin activity could be measured, corresponding to the generation of 17 pmol/ml/min of activated protein C when 1.5 μM human protein C was activated by 20 nM human α-thrombin in the presence of 5 mM CaCl2. After treatment by phospholipase C… Show more
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