Thrombolytic therapy reduces the incidence of left ventricular thrombus after anterior myocardial infarction: Relationship to vessel patency and infarct size

Abstract

These observations suggest that the presence of left ventricular thrombus is related to the extent of myocardial damage. Thrombolytic therapy reduces thrombus probably by salvaging myocardium at risk.

Determinants of left ventricular thrombus formation after primary percutaneous coronary intervention for anterior wall myocardial infarction

“…There are conflicting data regarding the use of thrombolysis and the incidence of LV thrombus. Data suggest that though the use of thrombolysis may not be associated with a lower incidence of LV thrombus, successful reperfusion with TIMI 2-3 flow does correlate with a decreased incidence [13,17]. In addition, the use of thrombolysis has been associated with a lower incidence of systemic embolization [16].…”

“…Studies show that early anticoagulation with heparin decreases the risk of LV thrombus formation [8][9][10][11][12]. Reperfusion therapy with thrombolysis has also been shown to decrease the incidence of LV thrombus thought to be secondary to decreased infarct size and preservation of LV function [13][14][15][16][17]. Two studies have evaluated the effect of percutaneous coronary intervention (PCI) on LV thrombus formation and report an incidence post AWMI of 10% and 15% [18,19].…”

Abciximab and left ventricular thrombus formation in early period of acute myocardial infarction treated with successful primary stenting

“…There is no consensus regarding the effectiveness of systemic thrombolysis in the prevention of this complication [20,[28][29][30][31]. Because a very low rate of LV thrombus was observed in patients with patent coronary artery in control angiography, the dominating opinion is that the minimizing of myocardium injury may be the mechanism by which thrombolytic agents reduce the incidence of this complication [3,30,32]. It turns out that heparin is more effective in preventing thrombus formation [20,25,[33][34][35].…”

Durchblutungsstörungen des Myokard

“…Einen wirksamen Schutz stellt dagegen das Kleinhalten des Infarktes durch eine frUhzeitige thrombolytische Therapie dar (s. PIZZETTI et al 1996). Aber auch Antikoagulanzien konnen die Entstehung muraler Thromben verhindern (VAITKUS u. BARNATHAN 1993), und die Auffassung von NIHOYANNOPOULOS et al (1989), daB die frUhe Morbiditat und Mortalitat bei muralen infarktbedingten Thromben geringer sei als bei fehlenden Thromben, lOste begriindeten Widerspruch aus (DALVI 1990 …”