Thrombolytic therapy for pulmonary embolism

Abstract

Based on the limited evidence found we cannot conclude whether thrombolytic therapy is better than heparin for pulmonary embolism. More double-blind RCTs, with subgroup analysis of patients presenting with haemodynamically stable acute pulmonary embolism compared to those patients with a haemodynamic unstable condition, are required.

Alteplase Treatment of Acute Pulmonary Embolism in the Intensive Care Unit

“…Therefore, these authors 50 recommend use of a thrombolytic agent in patients with a major pulmonary embolism and hemodynamic compromise. Dong et al 51 did not find any benefit of thrombolysis or any difference in hemorrhagic events between control and interventional groups. They concluded that evidence of any benefit from the use of thrombolytic agents rather than heparin in the treatment of acute pulmonary embolism is insufficient.…”

Alteplase Treatment of Acute Pulmonary Embolism in the Intensive Care Unit

“…Therefore, these authors 50 recommend use of a thrombolytic agent in patients with a major pulmonary embolism and hemodynamic compromise. Dong et al 51 did not find any benefit of thrombolysis or any difference in hemorrhagic events between control and interventional groups. They concluded that evidence of any benefit from the use of thrombolytic agents rather than heparin in the treatment of acute pulmonary embolism is insufficient.…”

Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis

“… 15 (9.1%) and Dong et al . 14 (10.4%). In contrast to our meta-analysis, these previous reports failed to demonstrate a significant association between thrombolytic therapy and major bleeding.…”

Efficacy evaluation of reteplase in a novel canine acute pulmonary thromboembolism model developed by minimally invasive surgery and digital subtraction angiography

“……”

Alteplase Treatment of Acute Pulmonary Embolism in the Intensive Care Unit

“…Therefore, these authors 50 recommend use of a thrombolytic agent in patients with a major pulmonary embolism and hemodynamic compromise. Dong et al 51 did not find any benefit of thrombolysis or any difference in hemorrhagic events between control and interventional groups. They concluded that evidence of any benefit from the use of thrombolytic agents rather than heparin in the treatment of acute pulmonary embolism is insufficient.…”

Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis

“… 15 (9.1%) and Dong et al . 14 (10.4%). In contrast to our meta-analysis, these previous reports failed to demonstrate a significant association between thrombolytic therapy and major bleeding.…”

Efficacy evaluation of reteplase in a novel canine acute pulmonary thromboembolism model developed by minimally invasive surgery and digital subtraction angiography

“……”

Alteplase Treatment of Acute Pulmonary Embolism in the Intensive Care Unit

“…Therefore, these authors 50 recommend use of a thrombolytic agent in patients with a major pulmonary embolism and hemodynamic compromise. Dong et al 51 did not find any benefit of thrombolysis or any difference in hemorrhagic events between control and interventional groups. They concluded that evidence of any benefit from the use of thrombolytic agents rather than heparin in the treatment of acute pulmonary embolism is insufficient.…”

Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis

“… 15 (9.1%) and Dong et al . 14 (10.4%). In contrast to our meta-analysis, these previous reports failed to demonstrate a significant association between thrombolytic therapy and major bleeding.…”

Efficacy evaluation of reteplase in a novel canine acute pulmonary thromboembolism model developed by minimally invasive surgery and digital subtraction angiography

“……”